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Open-label randomised controlled trial of aripiprazole/sertraline combination in comparison with quetiapine for the clinical and cost-effectiveness of treatment of bipolar depression (the ASCEnD study): study protocol.

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Title: Open-label randomised controlled trial of aripiprazole/sertraline combination in comparison with quetiapine for the clinical and cost-effectiveness of treatment of bipolar depression (the ASCEnD study): study protocol.
Authors: Azim L; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Al-Ashmori S; Biostatistics Research Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK., Butcher C; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK., Cipriani A; Oxford Health NHS Foundation Trust, Oxford, UK.; University of Oxford Department of Psychiatry, Oxford, UK., Chew-Graham CA; Keele University School of Medicine, Keele, UK., Clare E; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK., Clark E; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK., Cole M; Biostatistics Research Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK., Carella S; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Dixon L; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK., Evans J; Avon and Wiltshire Mental Health Partnership NHS Trust, Bath, UK.; Bristol Medical School, Bristol, UK., Gergel T; Bipolar UK, University College London Division of Psychiatry, London, UK.; Cardiff University Division of Psychological Medicine and Clinical Neurosciences, Cardiff, UK., Gibson J; The McPin Foundation, London, UK., Hancock HC; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK., Hoppe I; Keele University School of Medicine, Keele, UK., Kessler D; Bristol Medical School, Bristol, UK., Kabir T; University of Oxford Department of Psychiatry, Oxford, UK., Lewis G; University College London Division of Psychiatry, London, UK., Mathias A; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK., Morris R; Mental Health and Clinical Neurosciences, University of Nottingham School of Medicine, Nottingham, UK.; Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK., Nixon N; Mental Health and Clinical Neurosciences, University of Nottingham School of Medicine, Nottingham, UK.; Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK., Simon J; University of Oxford Department of Psychiatry, Oxford, UK.; Medical University of Vienna Department of Health Economics, Vienna, Austria., Teare MD; Biostatistics Research Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK., Wahba M; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Wall L; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Walmsley Z; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK., Wienand D; Medical University of Vienna Department of Health Economics, Vienna, Austria., Wolstenhulme F; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK., Ahuja N; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Watson S; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK stuart.watson@newcastle.ac.uk.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.
Corporate Authors: Lived Experience Advisory Panel
Source: BMJ open [BMJ Open] 2026 Mar 19; Vol. 16 (3), pp. e112677. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Open-label randomised controlled trial of aripiprazole/sertraline combination in comparison with quetiapine for the clinical and cost-effectiveness of treatment of bipolar depression (the ASCEnD study): study protocol.
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  Data: <searchLink fieldCode="AU" term="%22Azim+L%22">Azim L</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Al-Ashmori+S%22">Al-Ashmori S</searchLink>; Biostatistics Research Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Butcher+C%22">Butcher C</searchLink>; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Cipriani+A%22">Cipriani A</searchLink>; Oxford Health NHS Foundation Trust, Oxford, UK.; University of Oxford Department of Psychiatry, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chew-Graham+CA%22">Chew-Graham CA</searchLink>; Keele University School of Medicine, Keele, UK.<br /><searchLink fieldCode="AU" term="%22Clare+E%22">Clare E</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Clark+E%22">Clark E</searchLink>; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Cole+M%22">Cole M</searchLink>; Biostatistics Research Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Carella+S%22">Carella S</searchLink>; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Dixon+L%22">Dixon L</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Evans+J%22">Evans J</searchLink>; Avon and Wiltshire Mental Health Partnership NHS Trust, Bath, UK.; Bristol Medical School, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Gergel+T%22">Gergel T</searchLink>; Bipolar UK, University College London Division of Psychiatry, London, UK.; Cardiff University Division of Psychological Medicine and Clinical Neurosciences, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Gibson+J%22">Gibson J</searchLink>; The McPin Foundation, London, UK.<br /><searchLink fieldCode="AU" term="%22Hancock+HC%22">Hancock HC</searchLink>; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Hoppe+I%22">Hoppe I</searchLink>; Keele University School of Medicine, Keele, UK.<br /><searchLink fieldCode="AU" term="%22Kessler+D%22">Kessler D</searchLink>; Bristol Medical School, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Kabir+T%22">Kabir T</searchLink>; University of Oxford Department of Psychiatry, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+G%22">Lewis G</searchLink>; University College London Division of Psychiatry, London, UK.<br /><searchLink fieldCode="AU" term="%22Mathias+A%22">Mathias A</searchLink>; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Morris+R%22">Morris R</searchLink>; Mental Health and Clinical Neurosciences, University of Nottingham School of Medicine, Nottingham, UK.; Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Nixon+N%22">Nixon N</searchLink>; Mental Health and Clinical Neurosciences, University of Nottingham School of Medicine, Nottingham, UK.; Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Simon+J%22">Simon J</searchLink>; University of Oxford Department of Psychiatry, Oxford, UK.; Medical University of Vienna Department of Health Economics, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Teare+MD%22">Teare MD</searchLink>; Biostatistics Research Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Wahba+M%22">Wahba M</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Wall+L%22">Wall L</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Walmsley+Z%22">Walmsley Z</searchLink>; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Wienand+D%22">Wienand D</searchLink>; Medical University of Vienna Department of Health Economics, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wolstenhulme+F%22">Wolstenhulme F</searchLink>; Newcastle Clinical Trials Unit, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Ahuja+N%22">Ahuja N</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Watson+S%22">Watson S</searchLink>; Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK stuart.watson@newcastle.ac.uk.; Northern Centre for Mood Disorders, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.
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