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FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression.

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Title: FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression.
Authors: Guo Z; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China., Jiang H; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China.; Guangxi University of Chinese Medicine, Nanning, China., Wang X; The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, China., Xuan K; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China., Zhong H; Department of Oncology, Ji'an Central Hospital, Ji'an, China., Liu C; Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China., Zhang M; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China., Li Z; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China. liz_hichao@126.com., Huang W; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. hwrpony@szu.edu.cn.; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China. hwrpony@szu.edu.cn.; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. hwrpony@szu.edu.cn.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, China. hwrpony@szu.edu.cn.; GuangDong Engineering Technology Research Center for Clinical Application Of Cancer Genome, Shenzhen, China. hwrpony@szu.edu.cn., Sun Y; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. sunyangyang06@163.com.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 19; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression.
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  Data: <searchLink fieldCode="AU" term="%22Guo+Z%22">Guo Z</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China.; Guangxi University of Chinese Medicine, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, China.<br /><searchLink fieldCode="AU" term="%22Xuan+K%22">Xuan K</searchLink>; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Zhong+H%22">Zhong H</searchLink>; Department of Oncology, Ji'an Central Hospital, Ji'an, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China. liz_hichao@126.com.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. hwrpony@szu.edu.cn.; The First Affiliated Hospital, Shenzhen University; Shenzhen Second People's Hospital; Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, China. hwrpony@szu.edu.cn.; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. hwrpony@szu.edu.cn.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, China. hwrpony@szu.edu.cn.; GuangDong Engineering Technology Research Center for Clinical Application Of Cancer Genome, Shenzhen, China. hwrpony@szu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. sunyangyang06@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41420-026-03013-1
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        Text: English
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      – TitleFull: FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression.
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            – D: 19
              M: 03
              Text: 2026 Mar 19
              Type: published
              Y: 2026
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