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MDM2 Inhibition with Alrizomadlin (APG-115) in TP53 wild-type salivary gland cancers: a phase I clinical trial.

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Title: MDM2 Inhibition with Alrizomadlin (APG-115) in TP53 wild-type salivary gland cancers: a phase I clinical trial.
Authors: Pearson AT; University of Chicago Cancer Center, Chicago, IL, USA.; Chan Zuckerberg Biohub Chicago, Chicago, IL, USA., Muzaffar J; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kirtane K; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Bellile E; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Suresh K; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Rosenberg AJ; University of Chicago Cancer Center, Chicago, IL, USA., Worden F; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Chung CH; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Vokes E; University of Chicago Cancer Center, Chicago, IL, USA., Brenner JC; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Bhangale A; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., McHugh J; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Warner K; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Nor F; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Nor JE; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Innes K; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Zhai Y; Ascentage Pharma, Rockville, MD, USA., Fu T; Ascentage Pharma, Rockville, MD, USA., Swiecicki PL; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. pswiecic@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Mar 19; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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