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PROTECTOR / FIRE‑10: study protocol for a prospective, randomized, open-label, multicenter phase III trial to investigate the efficacy of preoperative systemic therapy in advanced colon cancer.

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Title: PROTECTOR / FIRE‑10: study protocol for a prospective, randomized, open-label, multicenter phase III trial to investigate the efficacy of preoperative systemic therapy in advanced colon cancer.
Authors: Siegel R; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Dittrich L; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Plewe J; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Denecke T; Department of Diagnostic and Interventional Radiology, University Medical Center Leipzig, Leipzig, Germany., Leonhardi J; Department of Diagnostic and Interventional Radiology, University Medical Center Leipzig, Leipzig, Germany., Tannapfel A; Institute of Pathology, Ruhr-Universität Bochum, Bochum, Germany., Reinacher-Schick A; Department of Hematology and Oncology, Katholisches Klinikum Bochum, Universitätsklinik der Ruhr-Universität Bochum, Bochum, Germany., Raschzok N; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, Berlin, Germany., Sauer IM; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Lauscher J; Department of General and Abdominal Surgery, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin , Berlin, Germany., Lorenzen S; Department of Hematology and Oncology, Technical University of Munich, Munich, Germany., Götze T; Krankenhaus Nordwest - University Cancer Center Frankfurt, Frankfurt, Germany., Jelas I; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Stahler A; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Kurreck A; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Ballhausen A; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Ostendorf BN; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Haase O; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Pratschke J; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Stintzing S; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; NCT- National Center for Tumor Diseases Berlin, Berlin, Germany., Modest DP; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. dominik.modest@charite.de.; NCT- National Center for Tumor Diseases Berlin, Berlin, Germany. dominik.modest@charite.de.
Source: BMC cancer [BMC Cancer] 2026 Mar 20; Vol. 26 (1). Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PROTECTOR / FIRE‑10: study protocol for a prospective, randomized, open-label, multicenter phase III trial to investigate the efficacy of preoperative systemic therapy in advanced colon cancer.
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  Data: <searchLink fieldCode="AU" term="%22Siegel+R%22">Siegel R</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dittrich+L%22">Dittrich L</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Plewe+J%22">Plewe J</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Denecke+T%22">Denecke T</searchLink>; Department of Diagnostic and Interventional Radiology, University Medical Center Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Leonhardi+J%22">Leonhardi J</searchLink>; Department of Diagnostic and Interventional Radiology, University Medical Center Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Tannapfel+A%22">Tannapfel A</searchLink>; Institute of Pathology, Ruhr-Universität Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Reinacher-Schick+A%22">Reinacher-Schick A</searchLink>; Department of Hematology and Oncology, Katholisches Klinikum Bochum, Universitätsklinik der Ruhr-Universität Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Raschzok+N%22">Raschzok N</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sauer+IM%22">Sauer IM</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lauscher+J%22">Lauscher J</searchLink>; Department of General and Abdominal Surgery, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin , Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenzen+S%22">Lorenzen S</searchLink>; Department of Hematology and Oncology, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Götze+T%22">Götze T</searchLink>; Krankenhaus Nordwest - University Cancer Center Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Jelas+I%22">Jelas I</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stahler+A%22">Stahler A</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kurreck+A%22">Kurreck A</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ballhausen+A%22">Ballhausen A</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ostendorf+BN%22">Ostendorf BN</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Haase+O%22">Haase O</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pratschke+J%22">Pratschke J</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stintzing+S%22">Stintzing S</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; NCT- National Center for Tumor Diseases Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Modest+DP%22">Modest DP</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. dominik.modest@charite.de.; NCT- National Center for Tumor Diseases Berlin, Berlin, Germany. dominik.modest@charite.de.
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  Data: <searchLink fieldCode="JN" term="%22100967800%22">BMC cancer</searchLink> [BMC Cancer] 2026 Mar 20; Vol. 26 (1). <i>Date of Electronic Publication: </i>2026 Mar 20.
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  Data: Journal Article; Clinical Trial Protocol
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100967800 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-2407 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214712407%22">14712407 </searchLink><i>NLM ISO Abbreviation: </i>BMC Cancer <i>Subsets: </i>MEDLINE
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