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TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination.

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Title: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination.
Authors: Zhang S; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Taizhou, Jiangsu, 225300, China., Wang Z; Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Cheng R; Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 31000, China., Yang X; Department of Neurology, Dazhou Central Hospital, Dazhou, Sichuan, 635099, China., Jiang A; Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Zhu L; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Taizhou, Jiangsu, 225300, China. zhuli@njmu.edu.cn., Qin X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China. qinxinyuecqmu@163.com.
Source: Journal of neuroinflammation [J Neuroinflammation] 2026 Mar 19; Vol. 23 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Taizhou, Jiangsu, 225300, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Cheng+R%22">Cheng R</searchLink>; Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 31000, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Neurology, Dazhou Central Hospital, Dazhou, Sichuan, 635099, China.<br /><searchLink fieldCode="AU" term="%22Jiang+A%22">Jiang A</searchLink>; Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Taizhou, Jiangsu, 225300, China. zhuli@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Qin+X%22">Qin X</searchLink>; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China. qinxinyuecqmu@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101222974%22">Journal of neuroinflammation</searchLink> [J Neuroinflammation] 2026 Mar 19; Vol. 23 (1). <i>Date of Electronic Publication: </i>2026 Mar 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101222974 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1742-2094 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217422094%22">17422094 </searchLink><i>NLM ISO Abbreviation: </i>J Neuroinflammation <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12974-026-03769-4
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      – Code: eng
        Text: English
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      – TitleFull: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination.
        Type: main
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            NameFull: Zhang S
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              Text: 2026 Mar 19
              Type: published
              Y: 2026
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