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An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration.

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Title: An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration.
Authors: Cheng SY; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Giguere D; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Kim S; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Seddon JM; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Caiazzi J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gross K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., McHugh N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Alterman JF; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gray-Edwards H; Department of Genetics and Cellular Medicine, Horae Gene Therapy Center and The Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Benatti HR; Department of Genetics and Cellular Medicine, Horae Gene Therapy Center and The Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Renner L; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA., Woolard H; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA., Stoddard J; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA., McGill TJ; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA., Neuringer M; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA., Brush RS; Department of Ophthalmology and the Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Agbaga MP; Department of Ophthalmology and the Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Departments of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Punzo C; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.; Department of Genetics and Cellular Medicine, Horae Gene Therapy Center and The Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2026 Feb 28; Vol. 37 (2), pp. 102878. Date of Electronic Publication: 2026 Feb 28 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
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  Data: An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+SY%22">Cheng SY</searchLink>; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Giguere+D%22">Giguere D</searchLink>; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Seddon+JM%22">Seddon JM</searchLink>; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Caiazzi+J%22">Caiazzi J</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Gross+K%22">Gross K</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22McHugh+N%22">McHugh N</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Echeverria+D%22">Echeverria D</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Alterman+JF%22">Alterman JF</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Gray-Edwards+H%22">Gray-Edwards H</searchLink>; Department of Genetics and Cellular Medicine, Horae Gene Therapy Center and The Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Benatti+HR%22">Benatti HR</searchLink>; Department of Genetics and Cellular Medicine, Horae Gene Therapy Center and The Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Renner+L%22">Renner L</searchLink>; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.<br /><searchLink fieldCode="AU" term="%22Woolard+H%22">Woolard H</searchLink>; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.<br /><searchLink fieldCode="AU" term="%22Stoddard+J%22">Stoddard J</searchLink>; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.<br /><searchLink fieldCode="AU" term="%22McGill+TJ%22">McGill TJ</searchLink>; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.<br /><searchLink fieldCode="AU" term="%22Neuringer+M%22">Neuringer M</searchLink>; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.<br /><searchLink fieldCode="AU" term="%22Brush+RS%22">Brush RS</searchLink>; Department of Ophthalmology and the Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.<br /><searchLink fieldCode="AU" term="%22Agbaga+MP%22">Agbaga MP</searchLink>; Department of Ophthalmology and the Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Departments of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.<br /><searchLink fieldCode="AU" term="%22Khvorova+A%22">Khvorova A</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Punzo+C%22">Punzo C</searchLink>; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.; Department of Genetics and Cellular Medicine, Horae Gene Therapy Center and The Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
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  Data: <searchLink fieldCode="JN" term="%22101581621%22">Molecular therapy. Nucleic acids</searchLink> [Mol Ther Nucleic Acids] 2026 Feb 28; Vol. 37 (2), pp. 102878. <i>Date of Electronic Publication: </i>2026 Feb 28 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101581621 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2162-2531 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221622531%22">21622531 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther Nucleic Acids <i>Subsets: </i>PubMed not MEDLINE
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