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Influence of Age in End-of-Life Practices in Worldwide ICUs (ETHICUS-2): A Prospective Observational Study.

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Title: Influence of Age in End-of-Life Practices in Worldwide ICUs (ETHICUS-2): A Prospective Observational Study.
Authors: Nagata I; Department of Intensive Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.; Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan., Sprung CL; Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Organization and Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel., Lautrette A; Medical Intensive Care Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France., Jaschinski U; Department of Anesthesiology and Critical Care Medicine, University Hospital Augsburg, Augsburg, Germany., Mullick S; Critical Care Medicine, Narayana Health Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, West Bengal, India., Aggarwal A; Department of General Anesthesiology, Department of Intensive Care and Resuscitation, Cleveland Clinic, Cleveland, OH., Pantazopoulos I; Department of Emergency Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, General University Hospital of Larissa, Larissa, Greece., Anstey MH; Intensive Care Department, Sir Charles Gairdner Hospital, Perth, WA, Australia., Jensen HI; Department of Anesthesiology and Intensive Care, University Hospital of Southern Denmark, Kolding, Denmark., Karlis G; ICU, Thoracic Diseases General Hospital 'Sotiria', Athens, Greece., Marliere MH; Department of Critical Care Medicine, CEDIMAT, Santo Domingo, Dominican Republic., Tsagkaris I; 2nd Department of Critical Care, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece., Montiel BE; Intensive Care Department, University Hospital La Paz, Madrid, Spain., Barrachina LG; Department of Intensive Care, Hospital General Universitario de Castellón, Castellón de la Plana, Spain., Weiss M; Department of Anesthesiology and Critical Care Medicine, University Hospital Augsburg, Augsburg, Germany., Romain M; Department of Medical Intensive Care, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Nunnally ME; New York University School of Medicine, New York, NY., Cerny V; Department of Anesthesiology, Perioperative Medicine and Intensive Care, Masaryk Hospital and J. E. Purkyne University, Usti nad Labem, Czech Republic.; Department of Anaesthesia and Intensive Care Medicine, Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech Republic., Piras C; Vitória Apart Hospital, Serra-ES, Brazil., Miskolci O; Intensive Care Unit, Mater Misericordiae University Hospital, Dublin, Ireland., Barth E; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Ulm, Ulm, Germany., Ricou B; Intensive Care, Department of Acute Medicine, Hospital of Geneva and University of Geneva, Geneva, Switzerland., Avidan A; Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Organization and Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
Corporate Authors: ETHICUS-2 Study Group
Source: Critical care medicine [Crit Care Med] 2026 Apr 01; Vol. 54 (4), pp. 701-714. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nagata+I%22">Nagata I</searchLink>; Department of Intensive Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.; Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Sprung+CL%22">Sprung CL</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Organization and Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Lautrette+A%22">Lautrette A</searchLink>; Medical Intensive Care Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Jaschinski+U%22">Jaschinski U</searchLink>; Department of Anesthesiology and Critical Care Medicine, University Hospital Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mullick+S%22">Mullick S</searchLink>; Critical Care Medicine, Narayana Health Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, West Bengal, India.<br /><searchLink fieldCode="AU" term="%22Aggarwal+A%22">Aggarwal A</searchLink>; Department of General Anesthesiology, Department of Intensive Care and Resuscitation, Cleveland Clinic, Cleveland, OH.<br /><searchLink fieldCode="AU" term="%22Pantazopoulos+I%22">Pantazopoulos I</searchLink>; Department of Emergency Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, General University Hospital of Larissa, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Anstey+MH%22">Anstey MH</searchLink>; Intensive Care Department, Sir Charles Gairdner Hospital, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Jensen+HI%22">Jensen HI</searchLink>; Department of Anesthesiology and Intensive Care, University Hospital of Southern Denmark, Kolding, Denmark.<br /><searchLink fieldCode="AU" term="%22Karlis+G%22">Karlis G</searchLink>; ICU, Thoracic Diseases General Hospital 'Sotiria', Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Marliere+MH%22">Marliere MH</searchLink>; Department of Critical Care Medicine, CEDIMAT, Santo Domingo, Dominican Republic.<br /><searchLink fieldCode="AU" term="%22Tsagkaris+I%22">Tsagkaris I</searchLink>; 2nd Department of Critical Care, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Montiel+BE%22">Montiel BE</searchLink>; Intensive Care Department, University Hospital La Paz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Barrachina+LG%22">Barrachina LG</searchLink>; Department of Intensive Care, Hospital General Universitario de Castellón, Castellón de la Plana, Spain.<br /><searchLink fieldCode="AU" term="%22Weiss+M%22">Weiss M</searchLink>; Department of Anesthesiology and Critical Care Medicine, University Hospital Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Romain+M%22">Romain M</searchLink>; Department of Medical Intensive Care, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Nunnally+ME%22">Nunnally ME</searchLink>; New York University School of Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Cerny+V%22">Cerny V</searchLink>; Department of Anesthesiology, Perioperative Medicine and Intensive Care, Masaryk Hospital and J. E. Purkyne University, Usti nad Labem, Czech Republic.; Department of Anaesthesia and Intensive Care Medicine, Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Piras+C%22">Piras C</searchLink>; Vitória Apart Hospital, Serra-ES, Brazil.<br /><searchLink fieldCode="AU" term="%22Miskolci+O%22">Miskolci O</searchLink>; Intensive Care Unit, Mater Misericordiae University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Barth+E%22">Barth E</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Ricou+B%22">Ricou B</searchLink>; Intensive Care, Department of Acute Medicine, Hospital of Geneva and University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Avidan+A%22">Avidan A</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Organization and Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel.
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