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Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues.

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Title: Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues.
Authors: Xu Y; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Huang Z; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Zhang Y; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Gong M; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Wang Z; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.; Department of Digestive Oncology, Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, China., Guo P; State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Institute for Immunology, Tsinghua University, Beijing, China., Zhang F; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Yang J; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Liang G; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Dong L; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Chang R; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Xia Y; State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Institute for Immunology, Tsinghua University, Beijing, China., Ni H; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Gong W; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Mei B; State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Institute for Immunology, Tsinghua University, Beijing, China., Gao Y; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Liu Z; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Shen L; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China., Li J; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China., Xu MM; State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Institute for Immunology, Tsinghua University, Beijing, China. michellexu@mail.tsinghua.edu.cn., Han D; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China. handl@big.ac.cn.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. handl@big.ac.cn.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. handl@big.ac.cn.
Source: Nature communications [Nat Commun] 2026 Mar 20; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gong+M%22">Gong M</searchLink>; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.; Department of Digestive Oncology, Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, China.<br /><searchLink fieldCode="AU" term="%22Guo+P%22">Guo P</searchLink>; State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Institute for Immunology, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; RNA Center for Cross-disciplinary Omics and Intelligent Decoding, China National Center for Bioinformation, Beijing, China.; State Key Laboratory of RNA Innovation, Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; College of Future Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liang+G%22">Liang G</searchLink>; 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