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Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.

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Title: Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.
Authors: Shah VJ; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany., Hartmann O; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany.; DKTK Munich, Munich, Germany., Wegner M; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany., Prieto-Garcia C; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.; Instituto de Biomedicina de Sevilla (IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla), Seville, Spain.; Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Seville, Spain., Kazi R; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany., von Heyl Zu Herrnsheim V; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany.; DKTK Munich, Munich, Germany., Wanli A; Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankurt, Frankfurt am Main, Germany., Mačinković I; Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankurt, Frankfurt am Main, Germany., Bohnacker B; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany.; DKTK Munich, Munich, Germany., Husnjak K; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany., Namgaladze D; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankurt, Frankfurt am Main, Germany., Rosenfeldt M; Institute of Pathology, University of Würzburg, Würzburg, Germany., Kaulich M; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Frankfurt am Main, Germany., Diefenbacher ME; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany. markus.diefenbacher@helmholtz-munich.de.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany. markus.diefenbacher@helmholtz-munich.de.; DKTK Munich, Munich, Germany. markus.diefenbacher@helmholtz-munich.de., Dikic I; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany. dikic@biochem2.uni-frankfurt.de.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany. dikic@biochem2.uni-frankfurt.de.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (9), pp. 3276-3305. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Shah+VJ%22">Shah VJ</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+O%22">Hartmann O</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany.; DKTK Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wegner+M%22">Wegner M</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Prieto-Garcia+C%22">Prieto-Garcia C</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.; Instituto de Biomedicina de Sevilla (IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla), Seville, Spain.; Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Kazi+R%22">Kazi R</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22von+Heyl+Zu+Herrnsheim+V%22">von Heyl Zu Herrnsheim V</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany.; DKTK Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wanli+A%22">Wanli A</searchLink>; Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Mačinković+I%22">Mačinković I</searchLink>; Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Bohnacker+B%22">Bohnacker B</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany.; DKTK Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Husnjak+K%22">Husnjak K</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Namgaladze+D%22">Namgaladze D</searchLink>; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenfeldt+M%22">Rosenfeldt M</searchLink>; Institute of Pathology, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kaulich+M%22">Kaulich M</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Diefenbacher+ME%22">Diefenbacher ME</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M),Germany, Member of the German Center for Lung Research (DZL), Neuherberg, Germany. markus.diefenbacher@helmholtz-munich.de.; Institute of Experimental Pneumology, Ludwig Maximilian University Munich, Munich, Germany. markus.diefenbacher@helmholtz-munich.de.; DKTK Munich, Munich, Germany. markus.diefenbacher@helmholtz-munich.de.<br /><searchLink fieldCode="AU" term="%22Dikic+I%22">Dikic I</searchLink>; Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany. dikic@biochem2.uni-frankfurt.de.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany. dikic@biochem2.uni-frankfurt.de.
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