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Real-world clinical utility of tumor whole-genome sequencing in solid cancers.

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Title: Real-world clinical utility of tumor whole-genome sequencing in solid cancers.
Authors: van Putten J; Hartwig Medical Foundation, Amsterdam, The Netherlands., Snaebjornsson P; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Bosch LJW; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Koster R; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Roepman P; Hartwig Medical Foundation, Amsterdam, The Netherlands.; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Usset J; Hartwig Medical Foundation, Amsterdam, The Netherlands., Boelens MC; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van Wezel T; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Rosenberg EH; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Marchetti S; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Vollebergh M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Lambregts DMJ; Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van der Kolk LE; Department of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands., Cuppen E; Hartwig Medical Foundation, Amsterdam, The Netherlands. e.cuppen@hartwigmedicalfoundation.nl.; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. e.cuppen@hartwigmedicalfoundation.nl., Nienhuis HH; Hartwig Medical Foundation, Amsterdam, The Netherlands.; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Monkhorst K; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands. k.monkhorst@nki.nl.
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1286-1295. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Real-world clinical utility of tumor whole-genome sequencing in solid cancers.
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  Data: <searchLink fieldCode="AU" term="%22van+Putten+J%22">van Putten J</searchLink>; Hartwig Medical Foundation, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Snaebjornsson+P%22">Snaebjornsson P</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Bosch+LJW%22">Bosch LJW</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koster+R%22">Koster R</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Roepman+P%22">Roepman P</searchLink>; Hartwig Medical Foundation, Amsterdam, The Netherlands.; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Usset+J%22">Usset J</searchLink>; Hartwig Medical Foundation, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boelens+MC%22">Boelens MC</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Wezel+T%22">van Wezel T</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rosenberg+EH%22">Rosenberg EH</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Marchetti+S%22">Marchetti S</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vollebergh+M%22">Vollebergh M</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lambregts+DMJ%22">Lambregts DMJ</searchLink>; Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Kolk+LE%22">van der Kolk LE</searchLink>; Department of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cuppen+E%22">Cuppen E</searchLink>; Hartwig Medical Foundation, Amsterdam, The Netherlands. e.cuppen@hartwigmedicalfoundation.nl.; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. e.cuppen@hartwigmedicalfoundation.nl.<br /><searchLink fieldCode="AU" term="%22Nienhuis+HH%22">Nienhuis HH</searchLink>; Hartwig Medical Foundation, Amsterdam, The Netherlands.; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Monkhorst+K%22">Monkhorst K</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands. k.monkhorst@nki.nl.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1286-1295. <i>Date of Electronic Publication: </i>2026 Mar 20.
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