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Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways.

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Title: Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways.
Authors: Del Ser-Badia A; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Soto-Faguás CM; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health Science University, Portland, OR, 97239, USA., Vecino R; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), 28002, Madrid, Spain.; Centro de Neurociencias Cajal, CSIC, Campus de Alcalá de Henares, 28805, Madrid, Spain., Vendrell C; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain., Molina-Porcel L; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Institute of Neurosciences, Universitat de Barcelona, 08036, Barcelona, Spain.; Neurological Tissue Bank, Biobanc-Hospital Clínic, FRCB/IDIBAPS, 08036, Barcelona, Spain., Sánchez-Valle R; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Institute of Neurosciences, Universitat de Barcelona, 08036, Barcelona, Spain., Rodríguez-Alvarez J; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain., Vicario C; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), 28002, Madrid, Spain.; Centro de Neurociencias Cajal, CSIC, Campus de Alcalá de Henares, 28805, Madrid, Spain., Saura CA; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain. carlos.saura@uab.cat.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. carlos.saura@uab.cat.; Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, 08208, Sabadell, Spain. carlos.saura@uab.cat.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Mar 20; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways.
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  Data: <searchLink fieldCode="AU" term="%22Del+Ser-Badia+A%22">Del Ser-Badia A</searchLink>; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.<br /><searchLink fieldCode="AU" term="%22Soto-Faguás+CM%22">Soto-Faguás CM</searchLink>; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Vecino+R%22">Vecino R</searchLink>; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), 28002, Madrid, Spain.; Centro de Neurociencias Cajal, CSIC, Campus de Alcalá de Henares, 28805, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vendrell+C%22">Vendrell C</searchLink>; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Molina-Porcel+L%22">Molina-Porcel L</searchLink>; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Institute of Neurosciences, Universitat de Barcelona, 08036, Barcelona, Spain.; Neurological Tissue Bank, Biobanc-Hospital Clínic, FRCB/IDIBAPS, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Valle+R%22">Sánchez-Valle R</searchLink>; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Institute of Neurosciences, Universitat de Barcelona, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Alvarez+J%22">Rodríguez-Alvarez J</searchLink>; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vicario+C%22">Vicario C</searchLink>; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), 28002, Madrid, Spain.; Centro de Neurociencias Cajal, CSIC, Campus de Alcalá de Henares, 28805, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Saura+CA%22">Saura CA</searchLink>; Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain. carlos.saura@uab.cat.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. carlos.saura@uab.cat.; Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, 08208, Sabadell, Spain. carlos.saura@uab.cat.
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