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Predictors of SARS-CoV-2 anti-Spike IgG antibody levels following two COVID-19 vaccine doses among children and adults in the Canadian CHILD Cohort.

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Title: Predictors of SARS-CoV-2 anti-Spike IgG antibody levels following two COVID-19 vaccine doses among children and adults in the Canadian CHILD Cohort.
Authors: Azeez R; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Ames SR; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Lotoski LC; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Winsor GL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Arnold CR; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Galipeau Y; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Pelchat M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Goguen S; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Simons E; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Moraes TJ; Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, ON, Canada., Mandhane PJ; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Turvey SE; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Bolotin S; Centre for Vaccine Preventable Diseases, University of Toronto: Dalla Lana School of Public Health, University of Toronto; Department of Laboratory Medicine and Pathobiology, University of Toronto; Public Health Ontario., Patrick DM; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre for Disease Control, Vancouver, BC, Canada., Bullard J; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Cadham Provincial Laboratory, Manitoba Health, Winnipeg, MB, Canada., Lix LM; Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada., Doucas N; CHILD Cohort Study National Parent Engagement Committee, Canada., Rodriguez N; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Brinkman FSL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Subbarao P; Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Langlois MA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Azad MB; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. Electronic address: meghan.azad@umanitoba.ca.
Source: Vaccine [Vaccine] 2026 Apr 19; Vol. 79, pp. 128342. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
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  Data: Predictors of SARS-CoV-2 anti-Spike IgG antibody levels following two COVID-19 vaccine doses among children and adults in the Canadian CHILD Cohort.
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  Data: <searchLink fieldCode="AU" term="%22Azeez+R%22">Azeez R</searchLink>; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Ames+SR%22">Ames SR</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Lotoski+LC%22">Lotoski LC</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Winsor+GL%22">Winsor GL</searchLink>; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Arnold+CR%22">Arnold CR</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Galipeau+Y%22">Galipeau Y</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pelchat+M%22">Pelchat M</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Goguen+S%22">Goguen S</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Simons+E%22">Simons E</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Moraes+TJ%22">Moraes TJ</searchLink>; Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mandhane+PJ%22">Mandhane PJ</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Turvey+SE%22">Turvey SE</searchLink>; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Bolotin+S%22">Bolotin S</searchLink>; Centre for Vaccine Preventable Diseases, University of Toronto: Dalla Lana School of Public Health, University of Toronto; Department of Laboratory Medicine and Pathobiology, University of Toronto; Public Health Ontario.<br /><searchLink fieldCode="AU" term="%22Patrick+DM%22">Patrick DM</searchLink>; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre for Disease Control, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Bullard+J%22">Bullard J</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Cadham Provincial Laboratory, Manitoba Health, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Lix+LM%22">Lix LM</searchLink>; Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Doucas+N%22">Doucas N</searchLink>; CHILD Cohort Study National Parent Engagement Committee, Canada.<br /><searchLink fieldCode="AU" term="%22Rodriguez+N%22">Rodriguez N</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Brinkman+FSL%22">Brinkman FSL</searchLink>; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Subbarao+P%22">Subbarao P</searchLink>; Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Langlois+MA%22">Langlois MA</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Azad+MB%22">Azad MB</searchLink>; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. Electronic address: meghan.azad@umanitoba.ca.
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