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Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis.

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Title: Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis.
Authors: Xu Y; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Weltzsch JP; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kilian C; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Steglich B; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Weiler-Normann C; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Dudek M; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Fackler J; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Wehmeyer MH; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Tintelnot J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; II. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Liebig LA; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Steinmann S; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Laschtowitz A; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Horst LJ; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schregel I; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Sebode M; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Hartl J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Casar C; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Lu J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schön G; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Zapf A; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Bono MR; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile., Rosemblatt MV; Faculty of Medicine, Universidad de los Andes, Chile., Nuñez S; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile., Castañeda J; Facultad de Medicina, Universidad de Chile, Santiago, Chile., Weidemann SA; Institute of Pathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kaiser N; Institute of Medical Systems Bioinformatics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schwerk M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kolster M; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Rattay G; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Ulrich H; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Sivayoganathan V; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Song N; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Krause J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Böttcher M; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Sagebiel A; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Wagner J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Krebs CF; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of Clinical Medicine, Aarhus University, Denmark; Department of Pathology, Aarhus University Hospital, Denmark., Hübner N; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Tolosa E; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Bonn S; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Huber S; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Knolle PA; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Herkel J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Adlung L; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schramm C; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Gagliani N; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: n.gagliani@uke.de., Lohse AW; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: a.lohse@uke.de.
Source: Journal of hepatology [J Hepatol] 2026 Jul; Vol. 85 (1), pp. 71-90. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis.
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Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Steglich+B%22">Steglich B</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Weiler-Normann+C%22">Weiler-Normann C</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dudek+M%22">Dudek M</searchLink>; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fackler+J%22">Fackler J</searchLink>; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wehmeyer+MH%22">Wehmeyer MH</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tintelnot+J%22">Tintelnot J</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; II. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Liebig+LA%22">Liebig LA</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Steinmann+S%22">Steinmann S</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. 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Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Casar+C%22">Casar C</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. 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Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwerk+M%22">Schwerk M</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kolster+M%22">Kolster M</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rattay+G%22">Rattay G</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ulrich+H%22">Ulrich H</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. 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Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Krause+J%22">Krause J</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Böttcher+M%22">Böttcher M</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sagebiel+A%22">Sagebiel A</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+J%22">Wagner J</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Krebs+CF%22">Krebs CF</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Puelles+VG%22">Puelles VG</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of Clinical Medicine, Aarhus University, Denmark; Department of Pathology, Aarhus University Hospital, Denmark.<br /><searchLink fieldCode="AU" term="%22Hübner+N%22">Hübner N</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Tolosa+E%22">Tolosa E</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bonn+S%22">Bonn S</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+S%22">Huber S</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Knolle+PA%22">Knolle PA</searchLink>; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Herkel+J%22">Herkel J</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Adlung+L%22">Adlung L</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schramm+C%22">Schramm C</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gagliani+N%22">Gagliani N</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: n.gagliani@uke.de.<br /><searchLink fieldCode="AU" term="%22Lohse+AW%22">Lohse AW</searchLink>; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: a.lohse@uke.de.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2026 Jul; Vol. 85 (1), pp. 71-90. <i>Date of Electronic Publication: </i>2026 Mar 19.
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          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1600-0641
          Numbering:
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              Value: 85
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of hepatology
              Type: main
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