Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis.
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| Title: | Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis. |
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| Authors: | Xu Y; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Weltzsch JP; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kilian C; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Steglich B; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Weiler-Normann C; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Dudek M; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Fackler J; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Wehmeyer MH; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Tintelnot J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; II. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Liebig LA; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Steinmann S; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Laschtowitz A; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Horst LJ; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schregel I; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Sebode M; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Hartl J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Casar C; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Lu J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schön G; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Zapf A; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Bono MR; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile., Rosemblatt MV; Faculty of Medicine, Universidad de los Andes, Chile., Nuñez S; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile., Castañeda J; Facultad de Medicina, Universidad de Chile, Santiago, Chile., Weidemann SA; Institute of Pathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kaiser N; Institute of Medical Systems Bioinformatics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schwerk M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kolster M; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Rattay G; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Ulrich H; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Sivayoganathan V; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Song N; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Krause J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Böttcher M; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Sagebiel A; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Wagner J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Krebs CF; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of Clinical Medicine, Aarhus University, Denmark; Department of Pathology, Aarhus University Hospital, Denmark., Hübner N; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Tolosa E; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Bonn S; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Huber S; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Knolle PA; Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Herkel J; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Adlung L; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Center for Biomedical AI (bAIome), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Schramm C; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Gagliani N; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Institute for Inflammation and Carcinogenesis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: n.gagliani@uke.de., Lohse AW; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: a.lohse@uke.de. |
| Source: | Journal of hepatology [J Hepatol] 2026 Jul; Vol. 85 (1), pp. 71-90. Date of Electronic Publication: 2026 Mar 19. |
| Publication Type: | Journal Article; Clinical Trial, Phase II |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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