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Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons.

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Title: Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons.
Authors: Chanoumidou K; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece. konstantina_chanoumidou@imbb.forth.gr.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece. konstantina_chanoumidou@imbb.forth.gr., Zota I; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Papadopoulou MA; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Konstantinou C; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Tsimpolis A; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Tsagliotis E; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Tziortziou M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg., Ntarntani K; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece., Grünewald A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg., Lavigne MD; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Gravanis A; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Charalampopoulos I; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece. charalampn@uoc.gr.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece. charalampn@uoc.gr.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 21; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chanoumidou+K%22">Chanoumidou K</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece. konstantina_chanoumidou@imbb.forth.gr.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece. konstantina_chanoumidou@imbb.forth.gr.<br /><searchLink fieldCode="AU" term="%22Zota+I%22">Zota I</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Papadopoulou+MA%22">Papadopoulou MA</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Konstantinou+C%22">Konstantinou C</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Tsimpolis+A%22">Tsimpolis A</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Tsagliotis+E%22">Tsagliotis E</searchLink>; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Tziortziou+M%22">Tziortziou M</searchLink>; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Ntarntani+K%22">Ntarntani K</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Grünewald+A%22">Grünewald A</searchLink>; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Lavigne+MD%22">Lavigne MD</searchLink>; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Gravanis+A%22">Gravanis A</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Charalampopoulos+I%22">Charalampopoulos I</searchLink>; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece. charalampn@uoc.gr.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece. charalampn@uoc.gr.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 Mar 21; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 21.
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              Text: 2026 Mar 21
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