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Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.

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Title: Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.
Authors: Harripaul R; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Rabia A; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; University of Health Sciences, Lahore, Pakistan.; CMH Lahore Medical College & Institute of Dentistry, Lahore, Pakistan., Vasli N; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Mikhailov A; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Rodrigues A; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Pastore SF; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Muhammad T; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Madanagopal TT; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Hashmi AN; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Tran C; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Stan C; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Aw K; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Zai CC; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Azam M; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan., Mahmood S; University of Health Sciences, Lahore, Pakistan.; NUR International University, Lahore, Pakistan., Heidari A; Sana Medical Genetics Laboratory, Reference Laboratory of Qazvin Medical University, Qazvin, Iran., Qamar R; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.; Science and Environment Sector, ICESCO, Rabat, Morocco., French L; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada., Tripathy S; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada., Agha Z; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.; Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA., Iqbal M; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Ghadami M; Department of Educational Sciences, Farhangian University, Tehran, Iran., Santangelo SL; Center for Clinical and Translational Research, Maine Health Institute for Research, Scarborough, ME, 04074, USA.; Department of Psychiatry, Tufts University School of Medicine, Boston, MA, 02110, USA., Bozorgmehr B; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Al Ayadhi L; Autism Research & Treatment Center, Department of Physiology, Faculty of Medicine, National Plan for Science and Technology (NPST), King Saud University, Riyadh, Saudi Arabia., Sasanfar R; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Maqbool S; The University of Child Health Sciences, Children's Hospital, Lahore, Pakistan., Hassan A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic & Translational Genetics Unit, Department of Medicine, Massachussets General Hospital, Boston, MA, USA.; University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.; Institute of Omics and Health Research, Lahore, Pakistan., Knowles JA; Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA., Ayub M; Department of Psychiatry, Queens University Kingston, Kingston, ON, Canada. m.ayub@ucl.ac.uk.; Division of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1T 7NF, UK. m.ayub@ucl.ac.uk., Vincent JB; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. john.vincent@camh.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, ON, M5T 1R8, Canada. john.vincent@camh.ca.
Source: Scientific reports [Sci Rep] 2026 Mar 21; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.
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  Data: <searchLink fieldCode="AU" term="%22Harripaul+R%22">Harripaul R</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rabia+A%22">Rabia A</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; University of Health Sciences, Lahore, Pakistan.; CMH Lahore Medical College & Institute of Dentistry, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Vasli+N%22">Vasli N</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mikhailov+A%22">Mikhailov A</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rodrigues+A%22">Rodrigues A</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pastore+SF%22">Pastore SF</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Muhammad+T%22">Muhammad T</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Madanagopal+TT%22">Madanagopal TT</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hashmi+AN%22">Hashmi AN</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tran+C%22">Tran C</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Stan+C%22">Stan C</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Aw+K%22">Aw K</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zai+CC%22">Zai CC</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Azam+M%22">Azam M</searchLink>; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mahmood+S%22">Mahmood S</searchLink>; University of Health Sciences, Lahore, Pakistan.; NUR International University, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Heidari+A%22">Heidari A</searchLink>; Sana Medical Genetics Laboratory, Reference Laboratory of Qazvin Medical University, Qazvin, Iran.<br /><searchLink fieldCode="AU" term="%22Qamar+R%22">Qamar R</searchLink>; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.; Science and Environment Sector, ICESCO, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22French+L%22">French L</searchLink>; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tripathy+S%22">Tripathy S</searchLink>; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Agha+Z%22">Agha Z</searchLink>; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.; Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Iqbal+M%22">Iqbal M</searchLink>; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ghadami+M%22">Ghadami M</searchLink>; Department of Educational Sciences, Farhangian University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Santangelo+SL%22">Santangelo SL</searchLink>; Center for Clinical and Translational Research, Maine Health Institute for Research, Scarborough, ME, 04074, USA.; Department of Psychiatry, Tufts University School of Medicine, Boston, MA, 02110, USA.<br /><searchLink fieldCode="AU" term="%22Bozorgmehr+B%22">Bozorgmehr B</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Al+Ayadhi+L%22">Al Ayadhi L</searchLink>; Autism Research & Treatment Center, Department of Physiology, Faculty of Medicine, National Plan for Science and Technology (NPST), King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Sasanfar+R%22">Sasanfar R</searchLink>; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Maqbool+S%22">Maqbool S</searchLink>; The University of Child Health Sciences, Children's Hospital, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hassan+A%22">Hassan A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic & Translational Genetics Unit, Department of Medicine, Massachussets General Hospital, Boston, MA, USA.; University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.; Institute of Omics and Health Research, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Knowles+JA%22">Knowles JA</searchLink>; Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Ayub+M%22">Ayub M</searchLink>; Department of Psychiatry, Queens University Kingston, Kingston, ON, Canada. m.ayub@ucl.ac.uk.; Division of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1T 7NF, UK. m.ayub@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Vincent+JB%22">Vincent JB</searchLink>; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. john.vincent@camh.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, ON, M5T 1R8, Canada. john.vincent@camh.ca.
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