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Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan.

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Title: Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan.
Authors: Pascual JR; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Rivera I; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Nguyen H; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Ngo PT; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Hoang A; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Andrews EJ; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Rouanet J; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Wright ST; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Sordo L; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Kofler J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA., Ikonomovic MD; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lai F; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Mapstone M; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Christian BT; Departments of Medical Physics and Psychiatry, Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Lott IT; Department of Pediatrics, University of California, Irvine, CA, USA., Doran E; Department of Pediatrics, University of California, Irvine, CA, USA., Hom CL; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA., Harp J; Department of Neurology, University of Kentucky, Lexington, KY, USA., Schmitt F; Department of Neurology, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA., Tudorascu DL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Ances BM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Phelan M; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Liu L; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Flores-Aguilar L; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Head E; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA. heade@uci.edu.
Corporate Authors: Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators
Source: Acta neuropathologica [Acta Neuropathol] 2026 Mar 22; Vol. 151 (1). Date of Electronic Publication: 2026 Mar 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
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  Data: Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan.
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  Data: <searchLink fieldCode="AU" term="%22Pascual+JR%22">Pascual JR</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+I%22">Rivera I</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+H%22">Nguyen H</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Ngo+PT%22">Ngo PT</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+A%22">Hoang A</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+EJ%22">Andrews EJ</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Rouanet+J%22">Rouanet J</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Wright+ST%22">Wright ST</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Sordo+L%22">Sordo L</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Kofler+J%22">Kofler J</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ikonomovic+MD%22">Ikonomovic MD</searchLink>; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Departments of Medical Physics and Psychiatry, Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Handen+BL%22">Handen BL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Doran+E%22">Doran E</searchLink>; Department of Pediatrics, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hom+CL%22">Hom CL</searchLink>; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Harp+J%22">Harp J</searchLink>; Department of Neurology, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Schmitt+F%22">Schmitt F</searchLink>; Department of Neurology, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Phelan+M%22">Phelan M</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Flores-Aguilar+L%22">Flores-Aguilar L</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA. heade@uci.edu.
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer%27s+Biomarkers+Consortium–Down+Syndrome+%28ABC-DS%29+Investigators%22">Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2026 Mar 22; Vol. 151 (1). <i>Date of Electronic Publication: </i>2026 Mar 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0412041 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0533 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200016322%22">00016322 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol <i>Subsets: </i>MEDLINE
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