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Oral deucrictibant for on-demand treatment of hereditary angioedema attacks (RAPIDe-1): a randomised, double-blind, placebo-controlled, phase 2 trial.

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Title: Oral deucrictibant for on-demand treatment of hereditary angioedema attacks (RAPIDe-1): a randomised, double-blind, placebo-controlled, phase 2 trial.
Authors: Maurer M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Stobiecki M; Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland., Valerieva A; Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital Alexandrovska, Sofia, Bulgaria., Hakl R; Department of Clinical Immunology and Allergology, St. Anne's University Hospital in Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Staevska MT; Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital Alexandrovska, Sofia, Bulgaria., Bouillet L; National Reference Center for Angioedema (CREAK), Department of Internal Medicine, Grenoble Alpes University, Laboratoire T-RAIG, UMR 5525 TIMC-IMAG (UGA-CNRS), Grenoble, France., Du-Thanh A; Department of Dermatology, University Montpellier, Montpellier, France., Kessel A; Bnai Zion Medical Center, Technion-Israel Institute of Technology, Haifa, Israel., Kiani-Alikhan S; Department of Immunology, Royal Free London NHS Foundation Trust, London, UK., Magerl M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Reshef A; Allergy, Immunology and Angio-oedema Center, Barzilai University Hospital, Ashkelon, Israel., Baeza ML; Allergy Department, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases-U761, 1, Gregorio Marañón, Madrid, Spain., Fain O; Department of Internal Medicine, Sorbonne University, AP-HP, Saint Antoine Hospital, Paris, France., Farkas H; Department of Internal Medicine and Haematology, Hungarian Angioedema Center of Reference and Excellence, Semmelweis University, Budapest, Hungary., Greve J; Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Guilarte M; Department of Allergy, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Unit (VHIR), Barcelona, Spain., Jacobs JS; Allergy and Asthma Clinical Research, Walnut Creek, CA, USA., Li HH; Institute for Asthma and Allergy, Chevy Chase, MD, USA., Lleonart R; Allergology Department, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Manning ME; Allergy, Asthma and Immunology Associates, Scottsdale, AZ, USA., Sussman GL; Gordon Sussman Clinical Research, Toronto and Division of Clinical Immunology and Allergy, University of Toronto, Toronto, ON, Canada., Anderson J; Clinical Research Center of Alabama, AllerVie Health Birmingham, AL, USA., Chapdelaine H; CHU de Montréal, Université de Montréal, Montréal, Canada., Cohn DM; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Hagin D; Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel., Králíčková P; Institute of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic., Ritchie B; Division of Hematology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Spadaro G; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Napoli, Italy., Staubach P; Department of Dermatology, University Medicine Mainz, Mainz, Germany., Tarzi MD; Department of Medicine, Brighton and Sussex Medical School, Brighton, UK., Yang WH; Ottawa Allergy Research Corporation, Department of Medicine, University of Ottawa, Ottawa, ON, Canada., Jouvin MH; Pharvaris, Lexington, MA, USA., Crabbé R; RC Consultancy, Bassins, Switzerland., van Leeuwen S; SLC Consultancy, Woerden, Netherlands., Chen H; Pharvaris, Lexington, MA, USA., Zhu L; Pharvaris, Lexington, MA, USA., Knolle J; JCK Consult, Frankfurt, Germany., Lesage A; GrayMatters Consulting, Schilde, Belgium., Lu P; Pharvaris, Lexington, MA, USA., Riedl MA; Division of Allergy and Immunology, University of California San Diego, La Jolla, CA, USA. Electronic address: mriedl@health.ucsd.edu., Aygören-Pürsün E; Department of Pediatrics, Goethe University Frankfurt, Frankfurt am Main, Germany.
Source: The Lancet. Haematology [Lancet Haematol] 2026 Apr; Vol. 13 (4), pp. e200-e214. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oral deucrictibant for on-demand treatment of hereditary angioedema attacks (RAPIDe-1): a randomised, double-blind, placebo-controlled, phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Maurer+M%22">Maurer M</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stobiecki+M%22">Stobiecki M</searchLink>; Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Valerieva+A%22">Valerieva A</searchLink>; Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital Alexandrovska, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Hakl+R%22">Hakl R</searchLink>; Department of Clinical Immunology and Allergology, St. Anne's University Hospital in Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Staevska+MT%22">Staevska MT</searchLink>; Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital Alexandrovska, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Bouillet+L%22">Bouillet L</searchLink>; National Reference Center for Angioedema (CREAK), Department of Internal Medicine, Grenoble Alpes University, Laboratoire T-RAIG, UMR 5525 TIMC-IMAG (UGA-CNRS), Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Du-Thanh+A%22">Du-Thanh A</searchLink>; Department of Dermatology, University Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Kessel+A%22">Kessel A</searchLink>; Bnai Zion Medical Center, Technion-Israel Institute of Technology, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Kiani-Alikhan+S%22">Kiani-Alikhan S</searchLink>; Department of Immunology, Royal Free London NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Magerl+M%22">Magerl M</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; 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Department of Allergy, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Unit (VHIR), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Jacobs+JS%22">Jacobs JS</searchLink>; Allergy and Asthma Clinical Research, Walnut Creek, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+HH%22">Li HH</searchLink>; Institute for Asthma and Allergy, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lleonart+R%22">Lleonart R</searchLink>; Allergology Department, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Manning+ME%22">Manning ME</searchLink>; Allergy, Asthma and Immunology Associates, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Sussman+GL%22">Sussman GL</searchLink>; Gordon Sussman Clinical Research, Toronto and Division of Clinical Immunology and Allergy, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Anderson+J%22">Anderson J</searchLink>; 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