ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.
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| Title: | ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances. |
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| Authors: | Ehlers L; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany., Wouters M; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Pillay B; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Delafontaine S; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium., Bucciol G; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium., Baggio M; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Laboratory of Computational and Developmental Biology, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Dzhus M; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Hombrouck A; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Damerau A; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany., De Somer L; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Immunobiology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium., Schrijvers R; Department of Microbiology, Immunology and Transplantation, Allergy and Clinical immunology Research group, KU Leuven, Leuven, Belgium., Vanderschueren S; Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; European Reference Network for Immunodeficiency, Autoinflammatory, Autoimmune and Pediatric Rheumatic disease (ERN-RITA), Leuven, Belgium., Jacquemyn M; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Leuven, Belgium., Kallinich T; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany., Daelemans D; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Leuven, Belgium., Ghesquière B; Department of Cellular and Molecular Medicine, Laboratory of Applied Mass Spectrometry, KU Leuven, Leuven, Belgium., Agostinis P; Cell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium., Moens L; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Meyts I; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium. isabelle.meyts@uzleuven.be.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. isabelle.meyts@uzleuven.be. |
| Source: | Cell death discovery [Cell Death Discov] 2026 Mar 23; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2058-7716 |
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| DOI: | 10.1038/s41420-026-03027-9 |
