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ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.

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Title: ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.
Authors: Ehlers L; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany., Wouters M; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Pillay B; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Delafontaine S; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium., Bucciol G; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium., Baggio M; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Laboratory of Computational and Developmental Biology, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Dzhus M; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Hombrouck A; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Damerau A; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany., De Somer L; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Immunobiology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium., Schrijvers R; Department of Microbiology, Immunology and Transplantation, Allergy and Clinical immunology Research group, KU Leuven, Leuven, Belgium., Vanderschueren S; Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; European Reference Network for Immunodeficiency, Autoinflammatory, Autoimmune and Pediatric Rheumatic disease (ERN-RITA), Leuven, Belgium., Jacquemyn M; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Leuven, Belgium., Kallinich T; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany., Daelemans D; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Leuven, Belgium., Ghesquière B; Department of Cellular and Molecular Medicine, Laboratory of Applied Mass Spectrometry, KU Leuven, Leuven, Belgium., Agostinis P; Cell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium., Moens L; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium., Meyts I; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium. isabelle.meyts@uzleuven.be.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. isabelle.meyts@uzleuven.be.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 23; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.
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  Data: <searchLink fieldCode="AU" term="%22Ehlers+L%22">Ehlers L</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wouters+M%22">Wouters M</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Pillay+B%22">Pillay B</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Delafontaine+S%22">Delafontaine S</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Bucciol+G%22">Bucciol G</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Baggio+M%22">Baggio M</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.; Laboratory of Computational and Developmental Biology, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dzhus+M%22">Dzhus M</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Hombrouck+A%22">Hombrouck A</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Damerau+A%22">Damerau A</searchLink>; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22De+Somer+L%22">De Somer L</searchLink>; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Immunobiology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schrijvers+R%22">Schrijvers R</searchLink>; Department of Microbiology, Immunology and Transplantation, Allergy and Clinical immunology Research group, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanderschueren+S%22">Vanderschueren S</searchLink>; Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; European Reference Network for Immunodeficiency, Autoinflammatory, Autoimmune and Pediatric Rheumatic disease (ERN-RITA), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jacquemyn+M%22">Jacquemyn M</searchLink>; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Kallinich+T%22">Kallinich T</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Daelemans+D%22">Daelemans D</searchLink>; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ghesquière+B%22">Ghesquière B</searchLink>; Department of Cellular and Molecular Medicine, Laboratory of Applied Mass Spectrometry, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Agostinis+P%22">Agostinis P</searchLink>; Cell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Moens+L%22">Moens L</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Meyts+I%22">Meyts I</searchLink>; Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium. isabelle.meyts@uzleuven.be.; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. isabelle.meyts@uzleuven.be.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Mar 23; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Mar 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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