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A randomized controlled clinical trial of intranasal versus subcutaneous midazolam for agitation in terminal illness (MinTU study).

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Title: A randomized controlled clinical trial of intranasal versus subcutaneous midazolam for agitation in terminal illness (MinTU study).
Authors: Hirschinger H; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.; Pharmacy, Mannheim University Hospital, Mannheim, Germany., Rémi C; Hospital Pharmacy and Department of Palliative Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Jäger E; Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Nittka S; Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Hetjens S; Department of Medical Statistics, Biomathematics and Information Processing, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Saussele S; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Merx K; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Koch J; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Abba M; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Ghazal M; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Hofheinz RD; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Michaeli T; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Sperk E; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Kohlbrenner K; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Hofmann WK; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany., Gencer D; Oeschelbronn Clinic, Centre for Integrative Oncology, Pain and Palliative Medicine, Oeschelbronn, Germany., Boch T; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.
Source: Palliative medicine [Palliat Med] 2026 Jun; Vol. 40 (6), pp. 856-867. Date of Electronic Publication: 2026 Mar 22.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Comparative Study
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 8704926 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-030X (Electronic) Linking ISSN: 02692163 NLM ISO Abbreviation: Palliat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A randomized controlled clinical trial of intranasal versus subcutaneous midazolam for agitation in terminal illness (MinTU study).
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  Data: <searchLink fieldCode="AU" term="%22Hirschinger+H%22">Hirschinger H</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.; Pharmacy, Mannheim University Hospital, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Rémi+C%22">Rémi C</searchLink>; Hospital Pharmacy and Department of Palliative Medicine, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+E%22">Jäger E</searchLink>; Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Nittka+S%22">Nittka S</searchLink>; Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Hetjens+S%22">Hetjens S</searchLink>; Department of Medical Statistics, Biomathematics and Information Processing, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Saussele+S%22">Saussele S</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Merx+K%22">Merx K</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+J%22">Koch J</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Abba+M%22">Abba M</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Ghazal+M%22">Ghazal M</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Hofheinz+RD%22">Hofheinz RD</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Michaeli+T%22">Michaeli T</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Sperk+E%22">Sperk E</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Kohlbrenner+K%22">Kohlbrenner K</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+WK%22">Hofmann WK</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Gencer+D%22">Gencer D</searchLink>; Oeschelbronn Clinic, Centre for Integrative Oncology, Pain and Palliative Medicine, Oeschelbronn, Germany.<br /><searchLink fieldCode="AU" term="%22Boch+T%22">Boch T</searchLink>; 3rd Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, University Medical Center Mannheim, Mannheim, Germany.
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  Data: <searchLink fieldCode="JN" term="%228704926%22">Palliative medicine</searchLink> [Palliat Med] 2026 Jun; Vol. 40 (6), pp. 856-867. <i>Date of Electronic Publication: </i>2026 Mar 22.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Comparative Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704926 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-030X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202692163%22">02692163 </searchLink><i>NLM ISO Abbreviation: </i>Palliat Med <i>Subsets: </i>MEDLINE
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