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Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.

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Title: Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.
Authors: Hinterleitner C; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Barthet VJA; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Goldberg HV; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA., Vogt KC; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Perea AM; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cancer Engineering Program, Gerstner Sloan Kettering School for Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ruiz S; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA., Hillger LR; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., McHugh D; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Ho YJ; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Chaves-Perez A; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Skamagki M; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Flowers S; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Rekhtman N; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Zhuang X; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Barretto GD; Flow Cytometry Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, 10065 USA., Li X; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Watson JT; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Luan W; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Simon J; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Tammela T; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Gardner R; Flow Cytometry Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, 10065 USA., Rudin CM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA., Romesser PB; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Bott MJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Filliol A; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Heller DA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA., Lowe SW; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 04. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.
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  Data: <searchLink fieldCode="AU" term="%22Hinterleitner+C%22">Hinterleitner C</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Barthet+VJA%22">Barthet VJA</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+HV%22">Goldberg HV</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA.<br /><searchLink fieldCode="AU" term="%22Vogt+KC%22">Vogt KC</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Perea+AM%22">Perea AM</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cancer Engineering Program, Gerstner Sloan Kettering School for Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+S%22">Ruiz S</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA.<br /><searchLink fieldCode="AU" term="%22Hillger+LR%22">Hillger LR</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22McHugh+D%22">McHugh D</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ho+YJ%22">Ho YJ</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chaves-Perez+A%22">Chaves-Perez A</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Skamagki+M%22">Skamagki M</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.<br /><searchLink fieldCode="AU" term="%22Flowers+S%22">Flowers S</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Rekhtman+N%22">Rekhtman N</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhuang+X%22">Zhuang X</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Barretto+GD%22">Barretto GD</searchLink>; Flow Cytometry Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, 10065 USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Watson+JT%22">Watson JT</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Luan+W%22">Luan W</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Simon+J%22">Simon J</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Tammela+T%22">Tammela T</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+R%22">Gardner R</searchLink>; Flow Cytometry Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, 10065 USA.<br /><searchLink fieldCode="AU" term="%22Rudin+CM%22">Rudin CM</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA.<br /><searchLink fieldCode="AU" term="%22Romesser+PB%22">Romesser PB</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Bott+MJ%22">Bott MJ</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.<br /><searchLink fieldCode="AU" term="%22Filliol+A%22">Filliol A</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Heller+DA%22">Heller DA</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York 10065, USA.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
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