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Global molecular landscape of early MASLD progression in human obesity.

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Title: Global molecular landscape of early MASLD progression in human obesity.
Authors: Zhao Q; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Cardiovascular & Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., De Nardo W; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia., Wang R; Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden., Zhong Y; Department of Physiology and Pharmacology and Centre of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., Keles U; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden., Sakalauskaite G; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden., Zhao LN; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden., Tay H; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Youhanna S; Department of Physiology and Pharmacology and Centre of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., Yan M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany., Xie Y; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany., Kim Y; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lee S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim RL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Teo G; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Narayanaswamy P; SCIEX, R&D, Singapore, Singapore., Burton PR; Department of Surgery, School of Translational Medicine, Monash University, Melbourne, Australia.; Australia and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia., Lauschke VM; Department of Physiology and Pharmacology and Centre of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany., Choi H; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Cardiovascular & Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Watt MJ; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia., Kaldis P; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden.
Source: ELife [Elife] 2026 Mar 23; Vol. 14. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Cardiovascular & Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22De+Nardo+W%22">De Nardo W</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Department of Physiology and Pharmacology and Centre of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Keles+U%22">Keles U</searchLink>; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Sakalauskaite+G%22">Sakalauskaite G</searchLink>; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhao+LN%22">Zhao LN</searchLink>; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Tay+H%22">Tay H</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Youhanna+S%22">Youhanna S</searchLink>; 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Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+G%22">Teo G</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Narayanaswamy+P%22">Narayanaswamy P</searchLink>; SCIEX, R&D, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Burton+PR%22">Burton PR</searchLink>; Department of Surgery, School of Translational Medicine, Monash University, Melbourne, Australia.; Australia and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Lauschke+VM%22">Lauschke VM</searchLink>; Department of Physiology and Pharmacology and Centre of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Choi+H%22">Choi H</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Cardiovascular & Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Watt+MJ%22">Watt MJ</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Kaldis+P%22">Kaldis P</searchLink>; Department of Clinical Sciences Malmö and Lund University Diabetes Centre (LUDC), Lund University, Clinical Research Centre (CRC), Malmö, Sweden.
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