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Multifunctional ACE2-nanobody fusion design for pan-specific neutralization and cardiovascular protection in SARS coronavirus infection.

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Title: Multifunctional ACE2-nanobody fusion design for pan-specific neutralization and cardiovascular protection in SARS coronavirus infection.
Authors: Sulea T; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.; Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada., Stuible M; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Moreno M; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Pelletier A; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Rossotti MA; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Cepero-Donates Y; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Slinn J; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Salois P; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Tran A; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Hewitt M; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Yogi A; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Rohani N; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Cass B; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Lenferink AEG; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Tanha J; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Center for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Ling B; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Lessard E; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Delafosse L; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada., Sandhu JK; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada., Stanimirovic D; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 May 06; Vol. 70 (5), pp. e0002426. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
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  Data: Multifunctional ACE2-nanobody fusion design for pan-specific neutralization and cardiovascular protection in SARS coronavirus infection.
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  Data: <searchLink fieldCode="AU" term="%22Sulea+T%22">Sulea T</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.; Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Stuible+M%22">Stuible M</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Moreno+M%22">Moreno M</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pelletier+A%22">Pelletier A</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rossotti+MA%22">Rossotti MA</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cepero-Donates+Y%22">Cepero-Donates Y</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Slinn+J%22">Slinn J</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Salois+P%22">Salois P</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tran+A%22">Tran A</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hewitt+M%22">Hewitt M</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yogi+A%22">Yogi A</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rohani+N%22">Rohani N</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Cass+B%22">Cass B</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Lenferink+AEG%22">Lenferink AEG</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tanha+J%22">Tanha J</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Center for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ling+B%22">Ling B</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lessard+E%22">Lessard E</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Delafosse+L%22">Delafosse L</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Sandhu+JK%22">Sandhu JK</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Stanimirovic+D%22">Stanimirovic D</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2026 May 06; Vol. 70 (5), pp. e0002426. <i>Date of Electronic Publication: </i>2026 Mar 23.
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