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Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models.

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Title: Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models.
Authors: Batra H; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Luo S; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710., Higgins JS; Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Jian F; Biomedical Pioneering Innovation Center, Peking University, Beijing 100871, China.; Changping Laboratory, Beijing 102206, China., Zhang J; Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115., Kibria MG; Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115., Jonaid GM; Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115., Zhou QJ; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Eaton A; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710., Cronin K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710., Mallory ML; Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Mattocks M; Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Edwards RJ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710., Parks R; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710., Lee EM; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710., Ye AY; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Williams AC; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Jung G; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Mansouri K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710., Alam SM; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710., Montefiori DC; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710., Tian M; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Baric RS; Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Cao Y; Biomedical Pioneering Innovation Center, Peking University, Beijing 100871, China.; Changping Laboratory, Beijing 102206, China., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710.; Department of Immunology, Duke University School of Medicine, Durham, NC 27710., Chen B; Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115., Alt FW; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2537053123. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Williams+AC%22">Williams AC</searchLink>; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Jung+G%22">Jung G</searchLink>; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Mansouri+K%22">Mansouri K</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.<br /><searchLink fieldCode="AU" term="%22Alam+SM%22">Alam SM</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710.<br /><searchLink fieldCode="AU" term="%22Montefiori+DC%22">Montefiori DC</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710.<br /><searchLink fieldCode="AU" term="%22Tian+M%22">Tian M</searchLink>; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Baric+RS%22">Baric RS</searchLink>; Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Biomedical Pioneering Innovation Center, Peking University, Beijing 100871, China.; Changping Laboratory, Beijing 102206, China.<br /><searchLink fieldCode="AU" term="%22Haynes+BF%22">Haynes BF</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710.; Department of Surgery, Duke University, Durham, NC 27710.; Department of Immunology, Duke University School of Medicine, Durham, NC 27710.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Alt+FW%22">Alt FW</searchLink>; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
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