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Health status and effects of spironolactone in people at high risk of heart failure: The Heart OMics in AGEing (HOMAGE) randomized trial.

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Title: Health status and effects of spironolactone in people at high risk of heart failure: The Heart OMics in AGEing (HOMAGE) randomized trial.
Authors: Aguiar-Neves I; Cardiology Department, Unidade Local de Saúde Gaia Espinho, 4434-502 Vila Nova de Gaia, Portugal; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: ana.ines.neves@ulsge.min-saude.pt., Diaz SO; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal., Pedro Ferreira J; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France., Girerd N; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France., Pellicori P; Robertson Center for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK., Mariottoni B; Department of Cardiology, Cortona Hospital, Arezzo, Italy., Cosmi F; Department of Cardiology, Cortona Hospital, Arezzo, Italy., Hazebroek M; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, Netherlands., Verdonschot JAJ; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, Netherlands., Cuthbert J; Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, UK., Petutschnigg J; Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin and German Center for Cardiovascular Research (DZHK), Berlin, Germany., Heymans S; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, Netherlands; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium., Staessen JA; Non-Profit Research Institute Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium; Biomedical Sciences Group, Faculty of Medicine, University of Leuven, Leuven, Belgium., Pieske B; Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin and German Center for Cardiovascular Research (DZHK), Berlin, Germany; Berlin Institute of Health, Berlin, Germany., Edelmann F; Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin and German Center for Cardiovascular Research (DZHK), Berlin, Germany., Clark AL; Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, UK., Rossignol P; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France., Fontes-Carvalho R; Cardiology Department, Unidade Local de Saúde Gaia Espinho, 4434-502 Vila Nova de Gaia, Portugal; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal., Cleland JG; Robertson Center for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK., Zannad F; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
Source: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology [Rev Port Cardiol] 2026 May; Vol. 45 (5), pp. 243-253. Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Lisbon Country of Publication: Portugal NLM ID: 8710716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2174-2030 (Electronic) Linking ISSN: 08702551 NLM ISO Abbreviation: Rev Port Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Health status and effects of spironolactone in people at high risk of heart failure: The Heart OMics in AGEing (HOMAGE) randomized trial.
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  Data: <searchLink fieldCode="AU" term="%22Aguiar-Neves+I%22">Aguiar-Neves I</searchLink>; Cardiology Department, Unidade Local de Saúde Gaia Espinho, 4434-502 Vila Nova de Gaia, Portugal; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: ana.ines.neves@ulsge.min-saude.pt.<br /><searchLink fieldCode="AU" term="%22Diaz+SO%22">Diaz SO</searchLink>; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Pedro+Ferreira+J%22">Pedro Ferreira J</searchLink>; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.<br /><searchLink fieldCode="AU" term="%22Girerd+N%22">Girerd N</searchLink>; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.<br /><searchLink fieldCode="AU" term="%22Pellicori+P%22">Pellicori P</searchLink>; Robertson Center for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Mariottoni+B%22">Mariottoni B</searchLink>; Department of Cardiology, Cortona Hospital, Arezzo, Italy.<br /><searchLink fieldCode="AU" term="%22Cosmi+F%22">Cosmi F</searchLink>; Department of Cardiology, Cortona Hospital, Arezzo, Italy.<br /><searchLink fieldCode="AU" term="%22Hazebroek+M%22">Hazebroek M</searchLink>; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Verdonschot+JAJ%22">Verdonschot JAJ</searchLink>; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Cuthbert+J%22">Cuthbert J</searchLink>; Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, UK.<br /><searchLink fieldCode="AU" term="%22Petutschnigg+J%22">Petutschnigg J</searchLink>; Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin and German Center for Cardiovascular Research (DZHK), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Heymans+S%22">Heymans S</searchLink>; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht, Netherlands; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Staessen+JA%22">Staessen JA</searchLink>; Non-Profit Research Institute Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium; Biomedical Sciences Group, Faculty of Medicine, University of Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Pieske+B%22">Pieske B</searchLink>; Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin and German Center for Cardiovascular Research (DZHK), Berlin, Germany; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Edelmann+F%22">Edelmann F</searchLink>; Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin and German Center for Cardiovascular Research (DZHK), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Clark+AL%22">Clark AL</searchLink>; Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, UK.<br /><searchLink fieldCode="AU" term="%22Rossignol+P%22">Rossignol P</searchLink>; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.<br /><searchLink fieldCode="AU" term="%22Fontes-Carvalho+R%22">Fontes-Carvalho R</searchLink>; Cardiology Department, Unidade Local de Saúde Gaia Espinho, 4434-502 Vila Nova de Gaia, Portugal; UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Cleland+JG%22">Cleland JG</searchLink>; Robertson Center for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Zannad+F%22">Zannad F</searchLink>; INSERM, Center d'Investigations Cliniques - Plurithématique 14-33, Université de Lorraine, and INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
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