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Heterologous saRNA prime - multivalent protein boost strategy induces broad and durable immunity against SARS-CoV-2 and MERS-CoV.

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Title: Heterologous saRNA prime - multivalent protein boost strategy induces broad and durable immunity against SARS-CoV-2 and MERS-CoV.
Authors: Renn D; KAUST Catalysis Center (KCC), Division of Physical Sciences & Engineering, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia.; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany., McPartlan JS; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA., Banala S; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany., Kiessling F; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany., Talukder P; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA., Mandl CW; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA. cmandl@tiba.bio., Eppinger J; KAUST Catalysis Center (KCC), Division of Physical Sciences & Engineering, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. jorg.eppinger@kaust.edu.sa.; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany. jorg.eppinger@kaust.edu.sa.; SAGEbio, LLC, 1 Broadway, Cambridge, MA, 02142, USA. jorg.eppinger@kaust.edu.sa., Chahal JS; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA. chahal@tiba.bio., Rueping M; KAUST Catalysis Center (KCC), Division of Physical Sciences & Engineering, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. magnus.rueping@kaust.edu.sa.; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany. magnus.rueping@kaust.edu.sa.; KAUST Center of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. magnus.rueping@kaust.edu.sa.; KAUST Center of Excellence for Generative AI, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. magnus.rueping@kaust.edu.sa.
Source: Scientific reports [Sci Rep] 2026 Mar 23; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Heterologous saRNA prime - multivalent protein boost strategy induces broad and durable immunity against SARS-CoV-2 and MERS-CoV.
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  Data: <searchLink fieldCode="AU" term="%22Renn+D%22">Renn D</searchLink>; KAUST Catalysis Center (KCC), Division of Physical Sciences & Engineering, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia.; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22McPartlan+JS%22">McPartlan JS</searchLink>; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Banala+S%22">Banala S</searchLink>; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kiessling+F%22">Kiessling F</searchLink>; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Talukder+P%22">Talukder P</searchLink>; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Mandl+CW%22">Mandl CW</searchLink>; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA. cmandl@tiba.bio.<br /><searchLink fieldCode="AU" term="%22Eppinger+J%22">Eppinger J</searchLink>; KAUST Catalysis Center (KCC), Division of Physical Sciences & Engineering, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. jorg.eppinger@kaust.edu.sa.; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany. jorg.eppinger@kaust.edu.sa.; SAGEbio, LLC, 1 Broadway, Cambridge, MA, 02142, USA. jorg.eppinger@kaust.edu.sa.<br /><searchLink fieldCode="AU" term="%22Chahal+JS%22">Chahal JS</searchLink>; Tiba Biotech, 1 Broadway, Cambridge, MA, 02142, USA. chahal@tiba.bio.<br /><searchLink fieldCode="AU" term="%22Rueping+M%22">Rueping M</searchLink>; KAUST Catalysis Center (KCC), Division of Physical Sciences & Engineering, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. magnus.rueping@kaust.edu.sa.; Institute for Experimental Molecular Imaging (ExMI), University Clinic, RWTH Aachen, Forckenbeckstraße 55, 52074, Aachen, Germany. magnus.rueping@kaust.edu.sa.; KAUST Center of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. magnus.rueping@kaust.edu.sa.; KAUST Center of Excellence for Generative AI, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia. magnus.rueping@kaust.edu.sa.
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              Text: 2026 Mar 23
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