An international, multicentre, interventional, randomised, assessor-blinded trial to MAXimise the METHotrexate therapy potential in patients with active rheumatoid arthritis (MethMax trial): study protocol for a randomised controlled trial.
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| Title: | An international, multicentre, interventional, randomised, assessor-blinded trial to MAXimise the METHotrexate therapy potential in patients with active rheumatoid arthritis (MethMax trial): study protocol for a randomised controlled trial. |
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| Authors: | Anderle K; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria., Sieghart D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria., Durechova M; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria., Bonnay F; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria., Kerschbaumer A; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria., Chatzidionysiou K; Department of Medicine, Solna, Division of Rheumatology, Karolinska University Hospital at Karolinska Institutet, Stockholm, Sweden., Knevel R; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Pitzalis C; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London & NIHR BRC Barts Health NHS Trust, London, UK., Lillegraven S; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway., Haavardsholm EA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Kristianslund EK; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway., Codreanu C; Center for Rheumatic Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Popescu C; Center for Rheumatic Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Gremese E; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., de Geest S; Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, BS, Switzerland., Kocher A; Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, BS, Switzerland., Makri S; Patient Research Partner, EULAR, Nicosia, Cyprus., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria., Lechner-Radner H; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria. helga.lechner-radner@meduniwien.ac.at. |
| Corporate Authors: | SQUEEZE Consortium |
| Source: | Trials [Trials] 2026 Mar 23; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 23. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41872937 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: An international, multicentre, interventional, randomised, assessor-blinded trial to MAXimise the METHotrexate therapy potential in patients with active rheumatoid arthritis (MethMax trial): study protocol for a randomised controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Anderle+K%22">Anderle K</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria.<br /><searchLink fieldCode="AU" term="%22Sieghart+D%22">Sieghart D</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria.<br /><searchLink fieldCode="AU" term="%22Durechova+M%22">Durechova M</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria.<br /><searchLink fieldCode="AU" term="%22Bonnay+F%22">Bonnay F</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria.<br /><searchLink fieldCode="AU" term="%22Kerschbaumer+A%22">Kerschbaumer A</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria.<br /><searchLink fieldCode="AU" term="%22Chatzidionysiou+K%22">Chatzidionysiou K</searchLink>; Department of Medicine, Solna, Division of Rheumatology, Karolinska University Hospital at Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Knevel+R%22">Knevel R</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Pitzalis+C%22">Pitzalis C</searchLink>; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London & NIHR BRC Barts Health NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lillegraven+S%22">Lillegraven S</searchLink>; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Haavardsholm+EA%22">Haavardsholm EA</searchLink>; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kristianslund+EK%22">Kristianslund EK</searchLink>; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Codreanu+C%22">Codreanu C</searchLink>; Center for Rheumatic Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Popescu+C%22">Popescu C</searchLink>; Center for Rheumatic Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Gremese+E%22">Gremese E</searchLink>; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22de+Geest+S%22">de Geest S</searchLink>; Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, BS, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kocher+A%22">Kocher A</searchLink>; Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, BS, Switzerland.<br /><searchLink fieldCode="AU" term="%22Makri+S%22">Makri S</searchLink>; Patient Research Partner, EULAR, Nicosia, Cyprus.<br /><searchLink fieldCode="AU" term="%22Aletaha+D%22">Aletaha D</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria.<br /><searchLink fieldCode="AU" term="%22Lechner-Radner+H%22">Lechner-Radner H</searchLink>; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Guertel 18-20, Vienna, A-1090, Austria. helga.lechner-radner@meduniwien.ac.at. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22SQUEEZE+Consortium%22">SQUEEZE Consortium</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Mar 23; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Mar 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41872937 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13063-026-09519-4 Languages: – Code: eng Text: English Titles: – TitleFull: An international, multicentre, interventional, randomised, assessor-blinded trial to MAXimise the METHotrexate therapy potential in patients with active rheumatoid arthritis (MethMax trial): study protocol for a randomised controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Anderle K – PersonEntity: Name: NameFull: Sieghart D – PersonEntity: Name: NameFull: Durechova M – PersonEntity: Name: NameFull: Bonnay F – PersonEntity: Name: NameFull: Kerschbaumer A – PersonEntity: Name: NameFull: Chatzidionysiou K – PersonEntity: Name: NameFull: Knevel R – PersonEntity: Name: NameFull: Pitzalis C – PersonEntity: Name: NameFull: Lillegraven S – PersonEntity: Name: NameFull: Haavardsholm EA – PersonEntity: Name: NameFull: Kristianslund EK – PersonEntity: Name: NameFull: Codreanu C – PersonEntity: Name: NameFull: Popescu C – PersonEntity: Name: NameFull: Gremese E – PersonEntity: Name: NameFull: de Geest S – PersonEntity: Name: NameFull: Kocher A – PersonEntity: Name: NameFull: Makri S – PersonEntity: Name: NameFull: Aletaha D – PersonEntity: Name: NameFull: Lechner-Radner H IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 03 Text: 2026 Mar 23 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1745-6215 Numbering: – Type: volume Value: 27 – Type: issue Value: 1 Titles: – TitleFull: Trials Type: main |
| ResultId | 1 |
