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Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression.

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Title: Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression.
Authors: Volynkina IA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia., Bortyazh MO; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Chen C-W; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA., Tereshchenkov AG; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Karakchieva AO; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Lukianov DA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia., Komarova ES; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Tupikin AE; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Novosibirsk Region, Russia., Skvortsov DA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Tevyashova AN; School of Science, Constructor University, Bremen, Germany., Tikhomirov AS; Laboratory of Synthesis of Antibiotics Overcoming Drug Resistance, Gause Institute of New Antibiotics, Moscow, Russia., Tashlitsky VN; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Kabilov MR; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Novosibirsk Region, Russia., Shchekotikhin AE; Laboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, Moscow, Russia., Dontsova OA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Department of Functioning of Living Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Polikanov YS; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois, USA., Sergiev PV; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 May 06; Vol. 70 (5), pp. e0153925. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
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  Data: Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression.
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  Data: <searchLink fieldCode="AU" term="%22Volynkina+IA%22">Volynkina IA</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Bortyazh+MO%22">Bortyazh MO</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Chen+C-W%22">Chen C-W</searchLink>; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Tereshchenkov+AG%22">Tereshchenkov AG</searchLink>; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Karakchieva+AO%22">Karakchieva AO</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Lukianov+DA%22">Lukianov DA</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Komarova+ES%22">Komarova ES</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Tupikin+AE%22">Tupikin AE</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Novosibirsk Region, Russia.<br /><searchLink fieldCode="AU" term="%22Skvortsov+DA%22">Skvortsov DA</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Tevyashova+AN%22">Tevyashova AN</searchLink>; School of Science, Constructor University, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Tikhomirov+AS%22">Tikhomirov AS</searchLink>; Laboratory of Synthesis of Antibiotics Overcoming Drug Resistance, Gause Institute of New Antibiotics, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Tashlitsky+VN%22">Tashlitsky VN</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Kabilov+MR%22">Kabilov MR</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Novosibirsk Region, Russia.<br /><searchLink fieldCode="AU" term="%22Shchekotikhin+AE%22">Shchekotikhin AE</searchLink>; Laboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Dontsova+OA%22">Dontsova OA</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Department of Functioning of Living Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Polikanov+YS%22">Polikanov YS</searchLink>; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Sergiev+PV%22">Sergiev PV</searchLink>; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Center for Molecular and Cellular Biology, Moscow, Russia.; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
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