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RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice.

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Title: RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice.
Authors: Trampel KA; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States., Gross KY; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States., O'Reilly D; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States.; Sealey Institute for Drug Discovery, University of Texas Medical Branch, Galveston, Texas, United States., Melisova A; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States., Salman B; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States., Green S; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States., George SA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States., Efimov IR; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States., Efimova T; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.
Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 May 01; Vol. 330 (5), pp. H1522-H1539. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice.
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  Data: <searchLink fieldCode="AU" term="%22Trampel+KA%22">Trampel KA</searchLink>; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Gross+KY%22">Gross KY</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22O'Reilly+D%22">O'Reilly D</searchLink>; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States.; Sealey Institute for Drug Discovery, University of Texas Medical Branch, Galveston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Melisova+A%22">Melisova A</searchLink>; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Salman+B%22">Salman B</searchLink>; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Green+S%22">Green S</searchLink>; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22George+SA%22">George SA</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.<br /><searchLink fieldCode="AU" term="%22Khvorova+A%22">Khvorova A</searchLink>; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Efimov+IR%22">Efimov IR</searchLink>; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Efimova+T%22">Efimova T</searchLink>; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901228 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203636135%22">03636135 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Heart Circ Physiol <i>Subsets: </i>MEDLINE
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        Value: 10.1152/ajpheart.00944.2025
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              Text: 2026 May 01
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