Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies.
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| Title: | Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG |
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| Authors: | Heisler J; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080., Hofmann JL; Department of AI for Drug Discovery, Genentech, Inc., South San Francisco, CA 94080., Tan Z; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080., Zarzar J; Department of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080., Izadi S; Department of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080., Carter PJ; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2526550123. Date of Electronic Publication: 2026 Mar 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1091-6490 |
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| DOI: | 10.1073/pnas.2526550123 |
