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Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies.

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Title: Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies.
Authors: Heisler J; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080., Hofmann JL; Department of AI for Drug Discovery, Genentech, Inc., South San Francisco, CA 94080., Tan Z; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080., Zarzar J; Department of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080., Izadi S; Department of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080., Carter PJ; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2526550123. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG<subscript>1</subscript> antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Heisler+J%22">Heisler J</searchLink>; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Hofmann+JL%22">Hofmann JL</searchLink>; Department of AI for Drug Discovery, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Tan+Z%22">Tan Z</searchLink>; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Zarzar+J%22">Zarzar J</searchLink>; Department of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Izadi+S%22">Izadi S</searchLink>; Department of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Carter+PJ%22">Carter PJ</searchLink>; Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2526550123. <i>Date of Electronic Publication: </i>2026 Mar 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE
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        Value: 10.1073/pnas.2526550123
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              Text: 2026 Mar 31
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