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Exploratory characterization of gut microbiota and cognitive profiles in adolescents with subthreshold depression: a shotgun metagenomics sequencing study.

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Title: Exploratory characterization of gut microbiota and cognitive profiles in adolescents with subthreshold depression: a shotgun metagenomics sequencing study.
Authors: Wang R; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Ma R; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Cai Y; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, PR China., Zhang L; Center of Mental Health, The Third People's Hospital of Liupanshui, Liupanshui, PR China., Lu W; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Zheng W; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Kong J; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Miao Q; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Li X; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Guan L; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Gao Y; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Chen K; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Kwan ATH; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Brain and Cognition Discovery Foundation, Toronto, ON, Canada., McIntyre RS; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Xu G; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China., Yu CK; Department of Counselling and Psychology, Hong Kong Shue Yan University, Hong Kong, PR China., Lam BY; Department of Counselling and Psychology, Hong Kong Shue Yan University, Hong Kong, PR China., So KF; Ministry of Education Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou, PR China., Lin K; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China. klin@cuhk.edu.cn.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China. klin@cuhk.edu.cn.; Department of Psychiatry and Behavioral Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, PR China. klin@cuhk.edu.cn.; Lecong Hospital of Shunde, Foshan, PR China. klin@cuhk.edu.cn.
Source: Npj mental health research [Npj Ment Health Res] 2026 Mar 24; Vol. 5 (1). Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918592488906676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-4251 (Electronic) Linking ISSN: 27314251 NLM ISO Abbreviation: Npj Ment Health Res Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Exploratory characterization of gut microbiota and cognitive profiles in adolescents with subthreshold depression: a shotgun metagenomics sequencing study.
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  Data: <searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Ma+R%22">Ma R</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Center of Mental Health, The Third People's Hospital of Liupanshui, Liupanshui, PR China.<br /><searchLink fieldCode="AU" term="%22Lu+W%22">Lu W</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Zheng+W%22">Zheng W</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Kong+J%22">Kong J</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Miao+Q%22">Miao Q</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Guan+L%22">Guan L</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Kwan+ATH%22">Kwan ATH</searchLink>; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22McIntyre+RS%22">McIntyre RS</searchLink>; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Yu+CK%22">Yu CK</searchLink>; Department of Counselling and Psychology, Hong Kong Shue Yan University, Hong Kong, PR China.<br /><searchLink fieldCode="AU" term="%22Lam+BY%22">Lam BY</searchLink>; Department of Counselling and Psychology, Hong Kong Shue Yan University, Hong Kong, PR China.<br /><searchLink fieldCode="AU" term="%22So+KF%22">So KF</searchLink>; Ministry of Education Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Department of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, PR China. klin@cuhk.edu.cn.; Guangdong Engineering Technology Research Center for Translational Medicine of MentalDisorders, Guangzhou, PR China. klin@cuhk.edu.cn.; Department of Psychiatry and Behavioral Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, PR China. klin@cuhk.edu.cn.; Lecong Hospital of Shunde, Foshan, PR China. klin@cuhk.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918592488906676%22">Npj mental health research</searchLink> [Npj Ment Health Res] 2026 Mar 24; Vol. 5 (1). <i>Date of Electronic Publication: </i>2026 Mar 24.
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        Value: 10.1038/s44184-026-00202-9
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