Enhanced dynamic risk stratification of smoldering multiple myeloma.
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| Title: | Enhanced dynamic risk stratification of smoldering multiple myeloma. |
|---|---|
| Authors: | Chabrun F; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Laboratory of Biochemistry and Molecular Biology, University Hospital of Angers, University of Angers, Angers, France., Schwartz DE; Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital Biostatistics, Somerville, MA, USA., Gentile S; Sapienza University of Rome, Rome, Italy., Mai EK; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany., Gupta TR; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Yale School of Medicine, New Haven, CT, USA., Perry J; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Cordas Dos Santos DM; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Hielscher T; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Werly A; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany., Schmidt SK; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany., Theodorakakou F; National and Kapodistrian University of Athens, Athens, Greece., Fotiou D; National and Kapodistrian University of Athens, Athens, Greece., Liacos CI; National and Kapodistrian University of Athens, Athens, Greece., Kanellias N; National and Kapodistrian University of Athens, Athens, Greece., Gisbert NC; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain., Martin-Sanchez E; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain., Termini R; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain., Waldschmidt J; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany., Chavda SJ; Department of Haematology, Cancer Institute, University College London, London, UK., Ainley L; Department of Haematology, Cancer Institute, University College London, London, UK., Da Vià MC; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., De Magistris C; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Pettine L; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Timonian MA; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Alberge JB; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Patel V; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Costello P; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tobia C; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Phan S; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lamb J; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Silverio MT; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Davis M; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., O'Donnell EK; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Marinac CR; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Nadeem O; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Bolli N; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Yong K; Department of Haematology, Cancer Institute, University College London, London, UK., Kortüm KM; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany., Einsele H; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany., Mateos MV; Department of Hematology, University Hospital of Salamanca/IBSAL/CIC/CIBERONC, Salamanca, Spain., Kumar S; Department of Hematology, Mayo Clinic Comprehensive Cancer Center, Rochester, MN, USA., San-Miguel JF; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain., Paiva B; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain., Kastritis E; National and Kapodistrian University of Athens, Athens, Greece., Dimopoulos MA; National and Kapodistrian University of Athens, Athens, Greece.; Department of Medicine, Korea University, Seoul, South Korea., Raab MS; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany., Trippa L; Departement of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. ltrippa@ds.dfci.harvard.edu., Ghobrial IM; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. irene_ghobrial@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. irene_ghobrial@dfci.harvard.edu. |
| Source: | Nature medicine [Nat Med] 2026 May; Vol. 32 (5), pp. 1745-1753. Date of Electronic Publication: 2026 Mar 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41876650 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enhanced dynamic risk stratification of smoldering multiple myeloma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chabrun+F%22">Chabrun F</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Laboratory of Biochemistry and Molecular Biology, University Hospital of Angers, University of Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Schwartz+DE%22">Schwartz DE</searchLink>; Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital Biostatistics, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gentile+S%22">Gentile S</searchLink>; Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mai+EK%22">Mai EK</searchLink>; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gupta+TR%22">Gupta TR</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Perry+J%22">Perry J</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cordas+Dos+Santos+DM%22">Cordas Dos Santos DM</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hielscher+T%22">Hielscher T</searchLink>; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Werly+A%22">Werly A</searchLink>; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+SK%22">Schmidt SK</searchLink>; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Theodorakakou+F%22">Theodorakakou F</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Fotiou+D%22">Fotiou D</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Liacos+CI%22">Liacos CI</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Kanellias+N%22">Kanellias N</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Gisbert+NC%22">Gisbert NC</searchLink>; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Martin-Sanchez+E%22">Martin-Sanchez E</searchLink>; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Termini+R%22">Termini R</searchLink>; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Waldschmidt+J%22">Waldschmidt J</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chavda+SJ%22">Chavda SJ</searchLink>; Department of Haematology, Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ainley+L%22">Ainley L</searchLink>; Department of Haematology, Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Da+Vià+MC%22">Da Vià MC</searchLink>; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Magistris+C%22">De Magistris C</searchLink>; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pettine+L%22">Pettine L</searchLink>; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Timonian+MA%22">Timonian MA</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alberge+JB%22">Alberge JB</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+V%22">Patel V</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Costello+P%22">Costello P</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tobia+C%22">Tobia C</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Phan+S%22">Phan S</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lamb+J%22">Lamb J</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Silverio+MT%22">Silverio MT</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Davis+M%22">Davis M</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22O'Donnell+EK%22">O'Donnell EK</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Marinac+CR%22">Marinac CR</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nadeem+O%22">Nadeem O</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bolli+N%22">Bolli N</searchLink>; Hematology section, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Yong+K%22">Yong K</searchLink>; Department of Haematology, Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kortüm+KM%22">Kortüm KM</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Einsele+H%22">Einsele H</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mateos+MV%22">Mateos MV</searchLink>; Department of Hematology, University Hospital of Salamanca/IBSAL/CIC/CIBERONC, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Department of Hematology, Mayo Clinic Comprehensive Cancer Center, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22San-Miguel+JF%22">San-Miguel JF</searchLink>; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Cancer Center Clinica Universidad de Navarra (CCUN), CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA) CIBER-ONC number CB16/12/00369, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Kastritis+E%22">Kastritis E</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Dimopoulos+MA%22">Dimopoulos MA</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.; Department of Medicine, Korea University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Raab+MS%22">Raab MS</searchLink>; Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital and Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Trippa+L%22">Trippa L</searchLink>; Departement of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. ltrippa@ds.dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Ghobrial+IM%22">Ghobrial IM</searchLink>; Center for Early Detection and Interception-Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. irene&#95;ghobrial@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. irene&#95;ghobrial@dfci.harvard.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 May; Vol. 32 (5), pp. 1745-1753. <i>Date of Electronic Publication: </i>2026 Mar 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE |
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