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An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females.

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Title: An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females.
Authors: Lukowicz C; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. celine.lukowicz@unil.ch., Winkler C; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Roger C; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Fowler JC; Wellcome Sanger Institute, Hinxton, UK., Tsai YC; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Clinical Research Institute for Inflammation Medicine, Medical Faculty, Johannes Kepler University, Linz, Austria., Meuli J; Department of Plastic and Hand Surgery, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Claudinot S; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Chang YT; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Clinical Research Institute for Inflammation Medicine, Medical Faculty, Johannes Kepler University, Linz, Austria., Iselin C; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Jones PH; Wellcome Sanger Institute, Hinxton, UK.; Department of Oncology, University of Cambridge, Cambridge, UK., Guenova E; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Clinical Research Institute for Inflammation Medicine, Medical Faculty, Johannes Kepler University, Linz, Austria.; Clinical Department of Immunodermatology, Kepler University Clinic and Medical Faculty, Johannes Kepler University, Linz, Austria., Jafari P; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Michalik L; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. liliane.michalik@unil.ch.
Source: EMBO reports [EMBO Rep] 2026 May; Vol. 27 (9), pp. 2434-2461. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lukowicz+C%22">Lukowicz C</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. celine.lukowicz@unil.ch.<br /><searchLink fieldCode="AU" term="%22Winkler+C%22">Winkler C</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roger+C%22">Roger C</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fowler+JC%22">Fowler JC</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Tsai+YC%22">Tsai YC</searchLink>; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Clinical Research Institute for Inflammation Medicine, Medical Faculty, Johannes Kepler University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Meuli+J%22">Meuli J</searchLink>; Department of Plastic and Hand Surgery, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Claudinot+S%22">Claudinot S</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chang+YT%22">Chang YT</searchLink>; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Clinical Research Institute for Inflammation Medicine, Medical Faculty, Johannes Kepler University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Iselin+C%22">Iselin C</searchLink>; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jones+PH%22">Jones PH</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Guenova+E%22">Guenova E</searchLink>; Department of Dermatology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Clinical Research Institute for Inflammation Medicine, Medical Faculty, Johannes Kepler University, Linz, Austria.; Clinical Department of Immunodermatology, Kepler University Clinic and Medical Faculty, Johannes Kepler University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Jafari+P%22">Jafari P</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Michalik+L%22">Michalik L</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. liliane.michalik@unil.ch.
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