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Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress.

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Title: Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress.
Authors: Lin YN; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan., Peng WH; School of Medicine, Collage of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, 300, Taiwan.; Institute of Biotechnology, Collage of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, 300, Taiwan., Huang YC; Department of Nephrology, New Taipei City Hospital, New Taipei City, Taiwan., Lai CY; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan., Hsu JR; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan., Wang JY; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Kao YC; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan., Wu LL; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan. wuliling@nycu.edu.tw.; Health Innovation Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wuliling@nycu.edu.tw.; Microbiota Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wuliling@nycu.edu.tw.
Source: Journal of translational medicine [J Transl Med] 2026 Mar 24; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress.
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  Data: <searchLink fieldCode="AU" term="%22Lin+YN%22">Lin YN</searchLink>; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peng+WH%22">Peng WH</searchLink>; School of Medicine, Collage of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, 300, Taiwan.; Institute of Biotechnology, Collage of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, 300, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YC%22">Huang YC</searchLink>; Department of Nephrology, New Taipei City Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+CY%22">Lai CY</searchLink>; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+JR%22">Hsu JR</searchLink>; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JY%22">Wang JY</searchLink>; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+YC%22">Kao YC</searchLink>; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+LL%22">Wu LL</searchLink>; Department and Institute of Physiology, National Yang Ming Chiao Tung University, No 155, Sec.2, Linong Street, Taipei, 112, Taiwan. wuliling@nycu.edu.tw.; Health Innovation Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wuliling@nycu.edu.tw.; Microbiota Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wuliling@nycu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Mar 24; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1186/s12967-026-08000-9
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      – Code: eng
        Text: English
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      – TitleFull: Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress.
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            NameFull: Lin YN
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            – D: 24
              M: 03
              Text: 2026 Mar 24
              Type: published
              Y: 2026
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