Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial.
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| Title: | Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial. |
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| Authors: | Murphy K; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. kmurphy@witshealth.co.za.; Department of Medicine, Wellcome Centre for Infectious Disease Research in Africa, and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. kmurphy@witshealth.co.za., Nel JS; Division of Infectious Diseases, Department of Medicine, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa., Moosa MY; Division of Infectious Disease, Department of Internal Medicine, Victoria Mxenge Hospital, Nelson R. Mandela School of Medicine. University of KwaZulu-Natal, Durban, South Africa., Wilson DP; Department of Internal Medicine, Harry Gwala Regional Hospital, Nelson R. Mandela School of Medicine. University of KwaZulu-Natal, Durban, South Africa., Tsitsi M; Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa., Mfinanga S; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania., Kivuyo S; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Kyazze D; Infectious Diseases Unit, Department of Internal Medicine, Livingstone Tertiary Hospital, Walter Sisulu University, Gqeberha, South Africa., Alam N; Department of Internal Medicine, Dora Nginza Hospital, Walter Sisulu University, Gqeberha, South Africa., Meintjes G; Department of Medicine and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Eriksson M; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Adams J; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK., Menezes C; Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa., Variava E; Department of Internal Medicine, Tshepong Hospital, University of the Witwatersrand, Klerksdorp, South Africa.; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Black J; Department of Medicine, Walter Sisulu University, Gqeberha, South Africa., Bremer M; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Medical Microbiology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa., Dat VQ; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam., Le T; Division of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA.; Tropical Medicine Research Center for Talaromycosis in Vietnam, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Schutz C; Department of Medicine, Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa., Loyse A; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK., Wake RM; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK., Lawrence DS; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Botswana Harvard Health Partnership, Gaborone, Botswana., Wang D; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Jaffar S; Institute for Global Health, University College London, London, UK., Jarvis JN; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Botswana Harvard Health Partnership, Gaborone, Botswana., Harrison TS; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK.; MRC Centre of Medical Mycology, University of Exeter, Exeter, UK., Molloy SF; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK., Govender NP; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. nelesh.govender@wits.ac.za.; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK. nelesh.govender@wits.ac.za.; MRC Centre of Medical Mycology, University of Exeter, Exeter, UK. nelesh.govender@wits.ac.za.; Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa. nelesh.govender@wits.ac.za. |
| Source: | Trials [Trials] 2026 Mar 24; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 24. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III; Comparative Study |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41877274 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Murphy+K%22">Murphy K</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. kmurphy@witshealth.co.za.; Department of Medicine, Wellcome Centre for Infectious Disease Research in Africa, and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. kmurphy@witshealth.co.za.<br /><searchLink fieldCode="AU" term="%22Nel+JS%22">Nel JS</searchLink>; Division of Infectious Diseases, Department of Medicine, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Moosa+MY%22">Moosa MY</searchLink>; Division of Infectious Disease, Department of Internal Medicine, Victoria Mxenge Hospital, Nelson R. Mandela School of Medicine. University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Wilson+DP%22">Wilson DP</searchLink>; Department of Internal Medicine, Harry Gwala Regional Hospital, Nelson R. Mandela School of Medicine. University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Tsitsi+M%22">Tsitsi M</searchLink>; Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Mfinanga+S%22">Mfinanga S</searchLink>; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania.<br /><searchLink fieldCode="AU" term="%22Kivuyo+S%22">Kivuyo S</searchLink>; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kyazze+D%22">Kyazze D</searchLink>; Infectious Diseases Unit, Department of Internal Medicine, Livingstone Tertiary Hospital, Walter Sisulu University, Gqeberha, South Africa.<br /><searchLink fieldCode="AU" term="%22Alam+N%22">Alam N</searchLink>; Department of Internal Medicine, Dora Nginza Hospital, Walter Sisulu University, Gqeberha, South Africa.<br /><searchLink fieldCode="AU" term="%22Meintjes+G%22">Meintjes G</searchLink>; Department of Medicine and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Eriksson+M%22">Eriksson M</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Adams+J%22">Adams J</searchLink>; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Menezes+C%22">Menezes C</searchLink>; Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Variava+E%22">Variava E</searchLink>; Department of Internal Medicine, Tshepong Hospital, University of the Witwatersrand, Klerksdorp, South Africa.; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Black+J%22">Black J</searchLink>; Department of Medicine, Walter Sisulu University, Gqeberha, South Africa.<br /><searchLink fieldCode="AU" term="%22Bremer+M%22">Bremer M</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Medical Microbiology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Dat+VQ%22">Dat VQ</searchLink>; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Le+T%22">Le T</searchLink>; Division of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA.; Tropical Medicine Research Center for Talaromycosis in Vietnam, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Schutz+C%22">Schutz C</searchLink>; Department of Medicine, Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Loyse+A%22">Loyse A</searchLink>; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wake+RM%22">Wake RM</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lawrence+DS%22">Lawrence DS</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Botswana Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Jaffar+S%22">Jaffar S</searchLink>; Institute for Global Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Jarvis+JN%22">Jarvis JN</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; Botswana Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Harrison+TS%22">Harrison TS</searchLink>; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK.; MRC Centre of Medical Mycology, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Molloy+SF%22">Molloy SF</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Govender+NP%22">Govender NP</searchLink>; Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. nelesh.govender@wits.ac.za.; Infection and Immunity Research Institute, School of Health and Medical Sciences City St George's, University of London, London, UK. nelesh.govender@wits.ac.za.; MRC Centre of Medical Mycology, University of Exeter, Exeter, UK. nelesh.govender@wits.ac.za.; Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa. nelesh.govender@wits.ac.za. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Mar 24; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Mar 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41877274 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13063-026-09520-x Languages: – Code: eng Text: English Titles: – TitleFull: Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Murphy K – PersonEntity: Name: NameFull: Nel JS – PersonEntity: Name: NameFull: Moosa MY – PersonEntity: Name: NameFull: Wilson DP – PersonEntity: Name: NameFull: Tsitsi M – PersonEntity: Name: NameFull: Mfinanga S – PersonEntity: Name: NameFull: Kivuyo S – PersonEntity: Name: NameFull: Kyazze D – PersonEntity: Name: NameFull: Alam N – PersonEntity: Name: NameFull: Meintjes G – PersonEntity: Name: NameFull: Eriksson M – PersonEntity: Name: NameFull: Adams J – PersonEntity: Name: NameFull: Menezes C – PersonEntity: Name: NameFull: Variava E – PersonEntity: Name: NameFull: Black J – PersonEntity: Name: NameFull: Bremer M – PersonEntity: Name: NameFull: Dat VQ – PersonEntity: Name: NameFull: Le T – PersonEntity: Name: NameFull: Schutz C – PersonEntity: Name: NameFull: Loyse A – PersonEntity: Name: NameFull: Wake RM – PersonEntity: Name: NameFull: Lawrence DS – PersonEntity: Name: NameFull: Wang D – PersonEntity: Name: NameFull: Jaffar S – PersonEntity: Name: NameFull: Jarvis JN – PersonEntity: Name: NameFull: Harrison TS – PersonEntity: Name: NameFull: Molloy SF – PersonEntity: Name: NameFull: Govender NP IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 03 Text: 2026 Mar 24 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1745-6215 Numbering: – Type: volume Value: 27 – Type: issue Value: 1 Titles: – TitleFull: Trials Type: main |
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