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New series of pentamidine-based 1,2,3-triazole-diaryl-hydrazones: design, synthesis, and evaluation of their leishmanicidal activity and mechanism of action against Leishmania (L.) amazonensis.

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Title: New series of pentamidine-based 1,2,3-triazole-diaryl-hydrazones: design, synthesis, and evaluation of their leishmanicidal activity and mechanism of action against Leishmania (L.) amazonensis.
Authors: Espuri Sepini PF; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Gontijo VS; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Tavares LM; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Souza LM; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Souza THF; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Couto DS; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Nunes JB; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Ribeiro CA; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal., da Silva Cravo SMM; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal., Zavan B; Laboratory for Antitumor Prototypes Evaluation, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG Brazil., Alves MA; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil., Souza HMR; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil., Ionta M; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil., Sousa ME; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal., Peloso EF; Department of Biochemistry, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG Brazil., Marques MJ; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Viegas C Jr; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880.
Source: RSC medicinal chemistry [RSC Med Chem] 2026 Feb 27. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem
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  Data: New series of pentamidine-based 1,2,3-triazole-diaryl-hydrazones: design, synthesis, and evaluation of their leishmanicidal activity and mechanism of action against Leishmania (L.) amazonensis.
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  Data: <searchLink fieldCode="AU" term="%22Espuri+Sepini+PF%22">Espuri Sepini PF</searchLink>; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576.<br /><searchLink fieldCode="AU" term="%22Gontijo+VS%22">Gontijo VS</searchLink>; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880.<br /><searchLink fieldCode="AU" term="%22Tavares+LM%22">Tavares LM</searchLink>; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880.<br /><searchLink fieldCode="AU" term="%22Souza+LM%22">Souza LM</searchLink>; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880.<br /><searchLink fieldCode="AU" term="%22Souza+THF%22">Souza THF</searchLink>; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576.<br /><searchLink fieldCode="AU" term="%22Couto+DS%22">Couto DS</searchLink>; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880.<br /><searchLink fieldCode="AU" term="%22Nunes+JB%22">Nunes JB</searchLink>; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576.<br /><searchLink fieldCode="AU" term="%22Ribeiro+CA%22">Ribeiro CA</searchLink>; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal.<br /><searchLink fieldCode="AU" term="%22da+Silva+Cravo+SMM%22">da Silva Cravo SMM</searchLink>; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal.<br /><searchLink fieldCode="AU" term="%22Zavan+B%22">Zavan B</searchLink>; Laboratory for Antitumor Prototypes Evaluation, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+MA%22">Alves MA</searchLink>; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+HMR%22">Souza HMR</searchLink>; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil.<br /><searchLink fieldCode="AU" term="%22Ionta+M%22">Ionta M</searchLink>; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+ME%22">Sousa ME</searchLink>; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal.<br /><searchLink fieldCode="AU" term="%22Peloso+EF%22">Peloso EF</searchLink>; Department of Biochemistry, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG Brazil.<br /><searchLink fieldCode="AU" term="%22Marques+MJ%22">Marques MJ</searchLink>; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576.<br /><searchLink fieldCode="AU" term="%22Viegas+C+Jr%22">Viegas C Jr</searchLink>; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880.
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