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PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification.

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Title: PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification.
Authors: Ge YS; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Huang CM; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Shen J; Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai, China.; Arthritis Institute of Integrated Traditional Chinese and Western Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Meng TT; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Zhao MJ; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Yin JL; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Huang XH; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Chen LL; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Luo JH; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Zhai YQ; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Du JW; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wang YL; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.; Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai, China., Wang XZ; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China., Sun PP; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Ding DF; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 09; Vol. 17, pp. 1730337. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification.
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  Data: <searchLink fieldCode="AU" term="%22Ge+YS%22">Ge YS</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+CM%22">Huang CM</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai, China.; Arthritis Institute of Integrated Traditional Chinese and Western Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Meng+TT%22">Meng TT</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+MJ%22">Zhao MJ</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yin+JL%22">Yin JL</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+XH%22">Huang XH</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+LL%22">Chen LL</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Luo+JH%22">Luo JH</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhai+YQ%22">Zhai YQ</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Du+JW%22">Du JW</searchLink>; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+YL%22">Wang YL</searchLink>; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.; Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+XZ%22">Wang XZ</searchLink>; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+PP%22">Sun PP</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ding+DF%22">Ding DF</searchLink>; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Mar 09; Vol. 17, pp. 1730337. <i>Date of Electronic Publication: </i>2026 Mar 09 (<i>Print Publication: </i>2026).
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        Value: 10.3389/fimmu.2026.1730337
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        Text: English
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