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Safety and immunologic impact of neoadjuvant/adjuvant GVAX, cyclophosphamide, pembrolizumab, and anti-CSF1R agent IMC-CS4 in pancreatic adenocarcinoma.

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Title: Safety and immunologic impact of neoadjuvant/adjuvant GVAX, cyclophosphamide, pembrolizumab, and anti-CSF1R agent IMC-CS4 in pancreatic adenocarcinoma.
Authors: Urman A; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Ding Y; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Durham J; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States., Wang H; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Qi H; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States., Narang A; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Burkhart R; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., He J; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Le D; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Laheru D; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Thompson E; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Jaffee E; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Purtell K; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Waisome-Stephens C; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Liu M; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Zheng L; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Mays Cancer Center at the University of Texas Health San Antonio MD Anderson Cancer Center, San Antonio, TX, United States., De Jesus-Acosta A; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 09; Vol. 17, pp. 1715761. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and immunologic impact of neoadjuvant/adjuvant GVAX, cyclophosphamide, pembrolizumab, and anti-CSF1R agent IMC-CS4 in pancreatic adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Urman+A%22">Urman A</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Durham+J%22">Durham J</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Qi+H%22">Qi H</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Narang+A%22">Narang A</searchLink>; 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Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Le+D%22">Le D</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Laheru+D%22">Laheru D</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Thompson+E%22">Thompson E</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Jaffee+E%22">Jaffee E</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Purtell+K%22">Purtell K</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Waisome-Stephens+C%22">Waisome-Stephens C</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Zheng+L%22">Zheng L</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Mays Cancer Center at the University of Texas Health San Antonio MD Anderson Cancer Center, San Antonio, TX, United States.<br /><searchLink fieldCode="AU" term="%22De+Jesus-Acosta+A%22">De Jesus-Acosta A</searchLink>; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Cancer Convergence Institute at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Pancreatic Cancer Precision Medicine Center of Excellence Program at Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
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