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An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans.

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Title: An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans.
Authors: Simpson JS; Seaport Therapeutics, Boston, MA, USA., Quach T; Seaport Therapeutics, Boston, MA, USA., Han S; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Hu L; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Trevaskis NL; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Leong NJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Sharma G; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Zheng D; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Paul SM; Seaport Therapeutics, Boston, MA, USA., Porter CJH; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Bonner DK; Seaport Therapeutics, Boston, MA, USA., Chen MC; Seaport Therapeutics, Boston, MA, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Mar 25; Vol. 18 (842), pp. eadu2352. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans.
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  Data: <searchLink fieldCode="AU" term="%22Simpson+JS%22">Simpson JS</searchLink>; Seaport Therapeutics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Quach+T%22">Quach T</searchLink>; Seaport Therapeutics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Trevaskis+NL%22">Trevaskis NL</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Leong+NJ%22">Leong NJ</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sharma+G%22">Sharma G</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Zheng+D%22">Zheng D</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Paul+SM%22">Paul SM</searchLink>; Seaport Therapeutics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Porter+CJH%22">Porter CJH</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bonner+DK%22">Bonner DK</searchLink>; Seaport Therapeutics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+MC%22">Chen MC</searchLink>; Seaport Therapeutics, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Mar 25; Vol. 18 (842), pp. eadu2352. <i>Date of Electronic Publication: </i>2026 Mar 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 25
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