Lactate-mediated macrophage polarization promotes splenomegaly in acute erythroleukemia.

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Title: Lactate-mediated macrophage polarization promotes splenomegaly in acute erythroleukemia.
Authors: Yang M; Guizhou University Medical College, Guiyang, China.; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.; Department of Medical Genetics, Guizhou Provincial People's Hospital, Guiyang, China.; Natural Products Research Center of Guizhou Province, Guiyang, China., Xie D; Guizhou University Medical College, Guiyang, China.; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.; Department of Medical Genetics, Guizhou Provincial People's Hospital, Guiyang, China.; Natural Products Research Center of Guizhou Province, Guiyang, China., Zhang Y; Guizhou University Medical College, Guiyang, China., Ye Y; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.; Natural Products Research Center of Guizhou Province, Guiyang, China., Yang S; Natural Products Research Center of Guizhou Province, Guiyang, China., Zhu H; Department of Haematology, Guizhou Provincial People's Hospital, Guiyang, China., Cheng S; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.; Natural Products Research Center of Guizhou Province, Guiyang, China., Yu J; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.; Natural Products Research Center of Guizhou Province, Guiyang, China., Zan N; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.; Natural Products Research Center of Guizhou Province, Guiyang, China., Huang S; Guizhou University Medical College, Guiyang, China. huangshengwen@gz5055.com.; Department of Medical Genetics, Guizhou Provincial People's Hospital, Guiyang, China. huangshengwen@gz5055.com., Luo H; Guizhou University Medical College, Guiyang, China. luoheng71050@aliyun.com.; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China. luoheng71050@aliyun.com.; Natural Products Research Center of Guizhou Province, Guiyang, China. luoheng71050@aliyun.com.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 25; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08612-5