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Deep learning-based precision phenotyping of spine curvature identifies novel genetic risk loci for scoliosis in the UK Biobank.

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Title: Deep learning-based precision phenotyping of spine curvature identifies novel genetic risk loci for scoliosis in the UK Biobank.
Authors: Zeosky M; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Kun E; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Reddy S; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Pandey D; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Xu L; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Wang JY; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Li C; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA., Gray RS; Department of Pediatrics, Dell Children's Medical Center of Central Texas, Austin, TX, USA.; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, USA., Wise CA; Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA., Otomo N; Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA., Narasimhan VM; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA. vagheesh@utexas.edu.; Department of Statistics and Data Science, The University of Texas at Austin, Austin, TX, USA. vagheesh@utexas.edu.
Source: NPJ digital medicine [NPJ Digit Med] 2026 Mar 26; Vol. 9 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101731738 Publication Model: Electronic Cited Medium: Internet ISSN: 2398-6352 (Electronic) Linking ISSN: 23986352 NLM ISO Abbreviation: NPJ Digit Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Deep learning-based precision phenotyping of spine curvature identifies novel genetic risk loci for scoliosis in the UK Biobank.
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  Data: <searchLink fieldCode="AU" term="%22Zeosky+M%22">Zeosky M</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kun+E%22">Kun E</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+S%22">Reddy S</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+D%22">Pandey D</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+JY%22">Wang JY</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gray+RS%22">Gray RS</searchLink>; Department of Pediatrics, Dell Children's Medical Center of Central Texas, Austin, TX, USA.; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wise+CA%22">Wise CA</searchLink>; Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Otomo+N%22">Otomo N</searchLink>; Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Narasimhan+VM%22">Narasimhan VM</searchLink>; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA. vagheesh@utexas.edu.; Department of Statistics and Data Science, The University of Texas at Austin, Austin, TX, USA. vagheesh@utexas.edu.
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  Data: <searchLink fieldCode="JN" term="%22101731738%22">NPJ digital medicine</searchLink> [NPJ Digit Med] 2026 Mar 26; Vol. 9 (1). <i>Date of Electronic Publication: </i>2026 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101731738 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2398-6352 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223986352%22">23986352 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Digit Med <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 26
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