Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury.
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| Title: | Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury. |
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| Authors: | Keeble AR; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Owen AM; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA., Thomas NT; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA., Gonzalez-Velez S; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Brightwell CR; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA., Barnes T; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA., Long DE; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA., Kern PA; Department of Internal Medicine, Division of Endocrinology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Conley CE; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Stone AV; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Johnson DL; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Wen Y; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Noehren B; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Fry CS; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA. cfr223@uky.edu.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA. cfr223@uky.edu. |
| Source: | BMC medicine [BMC Med] 2026 Mar 26; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41882639 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Keeble+AR%22">Keeble AR</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Owen+AM%22">Owen AM</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+NT%22">Thomas NT</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Velez+S%22">Gonzalez-Velez S</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Brightwell+CR%22">Brightwell CR</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+T%22">Barnes T</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.<br /><searchLink fieldCode="AU" term="%22Long+DE%22">Long DE</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.<br /><searchLink fieldCode="AU" term="%22Kern+PA%22">Kern PA</searchLink>; Department of Internal Medicine, Division of Endocrinology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Conley+CE%22">Conley CE</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Stone+AV%22">Stone AV</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+DL%22">Johnson DL</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Noehren+B%22">Noehren B</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Fry+CS%22">Fry CS</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA. cfr223@uky.edu.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA. cfr223@uky.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2026 Mar 26; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190723 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1741-7015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217417015%22">17417015 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41882639 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12916-026-04818-8 Languages: – Code: eng Text: English Titles: – TitleFull: Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Keeble AR – PersonEntity: Name: NameFull: Owen AM – PersonEntity: Name: NameFull: Thomas NT – PersonEntity: Name: NameFull: Gonzalez-Velez S – PersonEntity: Name: NameFull: Brightwell CR – PersonEntity: Name: NameFull: Barnes T – PersonEntity: Name: NameFull: Long DE – PersonEntity: Name: NameFull: Kern PA – PersonEntity: Name: NameFull: Conley CE – PersonEntity: Name: NameFull: Stone AV – PersonEntity: Name: NameFull: Johnson DL – PersonEntity: Name: NameFull: Wen Y – PersonEntity: Name: NameFull: Noehren B – PersonEntity: Name: NameFull: Fry CS IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 03 Text: 2026 Mar 26 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1741-7015 Numbering: – Type: volume Value: 24 – Type: issue Value: 1 Titles: – TitleFull: BMC medicine Type: main |
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