Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury.

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Title: Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury.
Authors: Keeble AR; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Owen AM; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA., Thomas NT; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA., Gonzalez-Velez S; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Brightwell CR; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA., Barnes T; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA., Long DE; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA., Kern PA; Department of Internal Medicine, Division of Endocrinology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Conley CE; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Stone AV; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Johnson DL; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Wen Y; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Noehren B; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Fry CS; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA. cfr223@uky.edu.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA. cfr223@uky.edu.
Source: BMC medicine [BMC Med] 2026 Mar 26; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Keeble+AR%22">Keeble AR</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Owen+AM%22">Owen AM</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+NT%22">Thomas NT</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Velez+S%22">Gonzalez-Velez S</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Brightwell+CR%22">Brightwell CR</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+T%22">Barnes T</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.<br /><searchLink fieldCode="AU" term="%22Long+DE%22">Long DE</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.<br /><searchLink fieldCode="AU" term="%22Kern+PA%22">Kern PA</searchLink>; Department of Internal Medicine, Division of Endocrinology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Conley+CE%22">Conley CE</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Stone+AV%22">Stone AV</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+DL%22">Johnson DL</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Noehren+B%22">Noehren B</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Fry+CS%22">Fry CS</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-020040536, USA. cfr223@uky.edu.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA. cfr223@uky.edu.
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