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Recent Progress in Sequence Optimization of mRNA Vaccine: Biological Mechanism, Quantitative Metrics, and Computational Model.

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Title: Recent Progress in Sequence Optimization of mRNA Vaccine: Biological Mechanism, Quantitative Metrics, and Computational Model.
Authors: Wang Y; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China., Cai Y; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.; Institute of Infection, Veterinary and Ecological Sciences, Liverpool, UK.; Themedium Therapeutics Co. Ltd., Suzhou, China., Wu Z; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China., Zhang J; Themedium Therapeutics Co. Ltd., Suzhou, China., Turtle L; Institute of Infection, Veterinary and Ecological Sciences, Liverpool, UK., Meng J; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Source: Bioinformatics and biology insights [Bioinform Biol Insights] 2026 Mar 14; Vol. 20, pp. 11779322261431255. Date of Electronic Publication: 2026 Mar 14 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101467187 Publication Model: eCollection Cited Medium: Print ISSN: 1177-9322 (Print) Linking ISSN: 11779322 NLM ISO Abbreviation: Bioinform Biol Insights Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.; Institute of Infection, Veterinary and Ecological Sciences, Liverpool, UK.; Themedium Therapeutics Co. Ltd., Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Themedium Therapeutics Co. Ltd., Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Turtle+L%22">Turtle L</searchLink>; Institute of Infection, Veterinary and Ecological Sciences, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Meng+J%22">Meng J</searchLink>; Department of Biosciences and Bioinformatics, Center for Intelligent RNA Therapeutics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
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              Text: 2026 Mar 14
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