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Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart.

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Title: Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart.
Authors: Schianchi F; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands. schianchif90@hotmail.it., Guns J; Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium., Bouwman FG; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands., Bogie JFJ; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium., Nabben M; Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands., Strzelecka A; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands., van Leeuwen R; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands., Kapsokalyvas D; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; Interdisciplinary Centre for Clinical Research IZKF, University Hospital RWTH Aachen, Aachen, Germany., Dennis KMJH; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Heather LC; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Wang S; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; Institute of Life Sciences, Chongqing Medical University, Chongqing, PR China., Glatz JFC; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands., Neumann D; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Departments of Pathology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands., Luiken JJFP; Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 26; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart.
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  Data: <searchLink fieldCode="AU" term="%22Schianchi+F%22">Schianchi F</searchLink>; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands. schianchif90@hotmail.it.<br /><searchLink fieldCode="AU" term="%22Guns+J%22">Guns J</searchLink>; Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.<br /><searchLink fieldCode="AU" term="%22Bouwman+FG%22">Bouwman FG</searchLink>; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bogie+JFJ%22">Bogie JFJ</searchLink>; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.<br /><searchLink fieldCode="AU" term="%22Nabben+M%22">Nabben M</searchLink>; Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Strzelecka+A%22">Strzelecka A</searchLink>; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Leeuwen+R%22">van Leeuwen R</searchLink>; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kapsokalyvas+D%22">Kapsokalyvas D</searchLink>; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; Interdisciplinary Centre for Clinical Research IZKF, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Dennis+KMJH%22">Dennis KMJH</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Heather+LC%22">Heather LC</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; Institute of Life Sciences, Chongqing Medical University, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Glatz+JFC%22">Glatz JFC</searchLink>; Department of Genetics & Cell Biology, Maastricht University, Maastricht, 6229 ER, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Neumann+D%22">Neumann D</searchLink>; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Departments of Pathology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Luiken+JJFP%22">Luiken JJFP</searchLink>; Department of Cardiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Mar 26; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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