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Integrated Multiomic Profiling Identifies BRD8/EP400 as a Pivotal Chromatin Module Mediating Anti-HER2 Response in HR+/HER2+ Breast Cancer.

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Title: Integrated Multiomic Profiling Identifies BRD8/EP400 as a Pivotal Chromatin Module Mediating Anti-HER2 Response in HR+/HER2+ Breast Cancer.
Authors: Gao A; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Khatri PH; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin., Ma G; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Liu P; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin., Fernandez-Martinez A; Lineberger Comprehensive Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Donahue K; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Wang Y; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Kim EJ; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Hu M; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Liu F; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Zhou J; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Chan NT; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Yang X; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Welch Schwartz R; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin., Ong IM; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin., Burkard ME; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Wisinski KB; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin., Perou CM; Lineberger Comprehensive Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Dinh HQ; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin., Xu W; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Source: Cancer research [Cancer Res] 2026 Jul 02; Vol. 86 (13), pp. 3287-3308.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Integrated Multiomic Profiling Identifies BRD8/EP400 as a Pivotal Chromatin Module Mediating Anti-HER2 Response in HR+/HER2+ Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Gao+A%22">Gao A</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Khatri+PH%22">Khatri PH</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Ma+G%22">Ma G</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Fernandez-Martinez+A%22">Fernandez-Martinez A</searchLink>; Lineberger Comprehensive Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Donahue+K%22">Donahue K</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Kim+EJ%22">Kim EJ</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Hu+M%22">Hu M</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Chan+NT%22">Chan NT</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Welch+Schwartz+R%22">Welch Schwartz R</searchLink>; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Ong+IM%22">Ong IM</searchLink>; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Burkard+ME%22">Burkard ME</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Wisinski+KB%22">Wisinski KB</searchLink>; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Perou+CM%22">Perou CM</searchLink>; Lineberger Comprehensive Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Dinh+HQ%22">Dinh HQ</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.; Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
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