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Final Efficacy and Safety Data From the Phase I/II ARROW Study of Pralsetinib in Patients With Advanced RET Fusion-Positive Non-Small Cell Lung Cancer.

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Title: Final Efficacy and Safety Data From the Phase I/II ARROW Study of Pralsetinib in Patients With Advanced RET Fusion-Positive Non-Small Cell Lung Cancer.
Authors: Besse B; Department of Cancer Medicine, Gustave Roussy Cancer Campus, Paris Saclay University, Villejuif, France., Subbiah V; UT MD Anderson Cancer Center, Houston, TX.; Sarah Cannon Research Institute, Nashville, TN., Curigliano G; Istituto Europeo di Oncologia, IRCCS, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy., Bowles DW; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO., Doebele RC; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO., Mansfield AS; Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN., Baik CS; Division of Medical Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA., de Lima Lopes G; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL., Paz-Ares L; Hospital Universitario 12 de Octubre, CNIO-H12O Lung Cancer Unit, Complutense University & Ciberonc, Madrid, Spain., Taylor MH; Earle A. Chiles Research Institute, Providence Medical Center, Portland, OR., Tan DSW; Department of Medical Oncology, National Cancer Center Singapore, Singapore, Singapore., Alonso G; Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Gadgeel SM; Division of Hematology/Oncology, Department of Medicine, Henry Ford Health, Detroit, MI., Kalemkerian GP; Department of Medicine, Hematology-Oncology, University of Michigan, Ann Arbor, MI., Ou SI; University of California Irvine School of Medicine, Orange, CA., van der Wekken AJ; Department of Pulmonology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Becerra CR; Hoag Family Cancer Institute, Newport Beach, CA., Evangelist M; New York Oncology Hematology, Albany, NY., Griesinger F; Department of Hematology and Oncology, Pius Hospital, University Medicine Oldenburg, Oldenburg, Germany., Liu SV; Georgetown University, Washington, DC., Lou Y; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL., Mazières J; Department of Thoracic Oncology, Centre Hospitalier Universitaire de Toulouse, Université Paul Sabatier, Toulouse, France., Melear JM; Texas Oncology-Austin Midtown, The US Oncology Network, Austin, TX., Narang M; US Oncology Research, Maryland Oncology Hematology, Columbia, MD., Saxena A; Division of Hematology & Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY., Thomas M; Department of Thoracic Oncology, Thoraxklinik, Heidelberg University Hospital and National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Wang S; Rigel Pharmaceuticals, Inc, South San Francisco, CA., Thomassen A; Rigel Pharmaceuticals, Inc, South San Francisco, CA., Lee DH; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Kim DW; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Gainor JF; Department of Medicine, Center for Thoracic Cancers, Massachusetts General Hospital Cancer Center, Boston, MA.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 May; Vol. 44 (13), pp. 1190-1197. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Final Efficacy and Safety Data From the Phase I/II ARROW Study of Pralsetinib in Patients With Advanced RET Fusion-Positive Non-Small Cell Lung Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Besse+B%22">Besse B</searchLink>; Department of Cancer Medicine, Gustave Roussy Cancer Campus, Paris Saclay University, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Subbiah+V%22">Subbiah V</searchLink>; UT MD Anderson Cancer Center, Houston, TX.; Sarah Cannon Research Institute, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Curigliano+G%22">Curigliano G</searchLink>; Istituto Europeo di Oncologia, IRCCS, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Bowles+DW%22">Bowles DW</searchLink>; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Doebele+RC%22">Doebele RC</searchLink>; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Mansfield+AS%22">Mansfield AS</searchLink>; Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Baik+CS%22">Baik CS</searchLink>; Division of Medical Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22de+Lima+Lopes+G%22">de Lima Lopes G</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Paz-Ares+L%22">Paz-Ares L</searchLink>; Hospital Universitario 12 de Octubre, CNIO-H12O Lung Cancer Unit, Complutense University & Ciberonc, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Taylor+MH%22">Taylor MH</searchLink>; Earle A. Chiles Research Institute, Providence Medical Center, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Tan+DSW%22">Tan DSW</searchLink>; Department of Medical Oncology, National Cancer Center Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Alonso+G%22">Alonso G</searchLink>; Medical Oncology Service, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gadgeel+SM%22">Gadgeel SM</searchLink>; Division of Hematology/Oncology, Department of Medicine, Henry Ford Health, Detroit, MI.<br /><searchLink fieldCode="AU" term="%22Kalemkerian+GP%22">Kalemkerian GP</searchLink>; Department of Medicine, Hematology-Oncology, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Ou+SI%22">Ou SI</searchLink>; University of California Irvine School of Medicine, Orange, CA.<br /><searchLink fieldCode="AU" term="%22van+der+Wekken+AJ%22">van der Wekken AJ</searchLink>; Department of Pulmonology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Becerra+CR%22">Becerra CR</searchLink>; Hoag Family Cancer Institute, Newport Beach, CA.<br /><searchLink fieldCode="AU" term="%22Evangelist+M%22">Evangelist M</searchLink>; New York Oncology Hematology, Albany, NY.<br /><searchLink fieldCode="AU" term="%22Griesinger+F%22">Griesinger F</searchLink>; Department of Hematology and Oncology, Pius Hospital, University Medicine Oldenburg, Oldenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+SV%22">Liu SV</searchLink>; Georgetown University, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Lou+Y%22">Lou Y</searchLink>; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL.<br /><searchLink fieldCode="AU" term="%22Mazières+J%22">Mazières J</searchLink>; Department of Thoracic Oncology, Centre Hospitalier Universitaire de Toulouse, Université Paul Sabatier, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Melear+JM%22">Melear JM</searchLink>; Texas Oncology-Austin Midtown, The US Oncology Network, Austin, TX.<br /><searchLink fieldCode="AU" term="%22Narang+M%22">Narang M</searchLink>; US Oncology Research, Maryland Oncology Hematology, Columbia, MD.<br /><searchLink fieldCode="AU" term="%22Saxena+A%22">Saxena A</searchLink>; Division of Hematology & Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Thomas+M%22">Thomas M</searchLink>; Department of Thoracic Oncology, Thoraxklinik, Heidelberg University Hospital and National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Rigel Pharmaceuticals, Inc, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Thomassen+A%22">Thomassen A</searchLink>; Rigel Pharmaceuticals, Inc, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Lee+DH%22">Lee DH</searchLink>; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+DW%22">Kim DW</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Gainor+JF%22">Gainor JF</searchLink>; Department of Medicine, Center for Thoracic Cancers, Massachusetts General Hospital Cancer Center, Boston, MA.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2026 May; Vol. 44 (13), pp. 1190-1197. <i>Date of Electronic Publication: </i>2026 Mar 26.
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