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Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial.

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Title: Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial.
Authors: Neyra JA; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA., Legrand M; Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California, San Francisco, CA, USA. Electronic address: matthieu.legrand@ucsf.edu., Tidswell MA; Pulmonary and Critical Care Division, Baystate Medical Center, Springfield, MA, USA., Al-Khafaji A; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Galphin C; Southeast Renal Research Institute, CHI Memorial Hospital, Chattanooga, TN, USA., Rains R; Pulmonary Associates, University of Colorado Health Memorial Hospital, Colorado Springs, CO, USA., Davison D; Department of Anesthesia and Critical Care, George Washington University Hospital, Washington, DC, USA., Tolwani A; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA., Chen JT; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA., Bender WS; Department of Medicine, Emory University, Atlanta, GA, USA., Busse LW; Department of Medicine, Emory University, Atlanta, GA, USA., Meena NK; Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., DellaVolpe J; Institute for Extracorporeal Life Support, Methodist Healthcare System, San Antonio, TX, USA., Williams GW; Department of Anesthesiology, Critical Care, and Pain Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Kashani KB; Division of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Gunnerson KJ; Departments of Emergency Medicine, Anesthesiology, and Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA., McMahon BA; Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, USA., Eaton J; Department of Medicine, Division of Pulmonary and Critical Care, Louisiana State University Health, Shreveport, LA, USA., Khan S; Department of Medicine, Stony Brook University Hospital, Stony Brook, NY, USA., Kohli-Seth R; Institute for Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jagpal S; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Klein D; Department of Critical Care, St Michael's Hospital, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Kamaluddin E; Spectral Medical, Toronto, ON, Canada., Foster DM; Spectral Medical, Toronto, ON, Canada., Walker PM; Spectral Medical, Toronto, ON, Canada., Tomlinson G; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Kellum JA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Spectral Medical, Toronto, ON, Canada.
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2026 May; Vol. 14 (5), pp. 443-452. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase III; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial.
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  Data: <searchLink fieldCode="JN" term="%22101605555%22">The Lancet. Respiratory medicine</searchLink> [Lancet Respir Med] 2026 May; Vol. 14 (5), pp. 443-452. <i>Date of Electronic Publication: </i>2026 Mar 23.
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