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Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study.

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Title: Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study.
Authors: Reddy K; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK; Royal Victoria Hospital, Belfast, UK. Electronic address: k.reddy@qub.ac.uk., Sinha P; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA., Antcliffe DB; Division of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, London, UK., McDowell C; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK., Bradley PA; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK., Black L; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK., Murphy L; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK., Barbaras J; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Conlon J; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Camporota L; Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, King's Health Partners, London, UK; Division of Asthma, Allergy and Lung Biology, King's College London, London, UK., Ostermann M; Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, King's Health Partners, London, UK., Hopkins P; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Szakmany T; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK; Critical Care Directorate, Royal Gwent Hospital, Newport, UK., Cherian S; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK; Critical Care Directorate, Royal Gwent Hospital, Newport, UK., Welters I; Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK; Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK., Brealey D; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK; Division of Critical Care, University College London Hospitals, London, UK., Parekh D; Birmingham Acute Care Research Group, University of Birmingham, Birmingham, UK; Department of Anaesthetics and Critical Care, Queen Elizabeth Hospital, Birmingham, UK., Rostron AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK; Department of Anaesthesia and Intensive Care Medicine, Sunderland Royal Hospital, Sunderland, UK., Bos LDJ; Department of Intensive Care and Laboratory of Experimental Intensive Care and Anaesthesiology, Amsterdam UMC, Amsterdam, Netherlands., Nichol A; Department of Critical Care Medicine, School of Medicine, University College Dublin, Health Sciences Centre, Belfield, Dublin, Ireland., Shankar-Hari M; Centre for Critical Illness Research, King's College London, London, UK; Institute for Regeneration and Repair, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK., Gordon AC; Division of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, London, UK., Delucchi K; Department of Psychiatry and Behavioural Sciences, University of California San Francisco, San Francisco, CA, USA., O'Kane CM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Matthay MA; Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA., Calfee CS; Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA., McAuley DF; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK; Royal Victoria Hospital, Belfast, UK.
Corporate Authors: PHIND Investigators
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2026 Jul; Vol. 14 (7), pp. 589-600. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
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  Data: Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Reddy+K%22">Reddy K</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK; Royal Victoria Hospital, Belfast, UK. Electronic address: k.reddy@qub.ac.uk.<br /><searchLink fieldCode="AU" term="%22Sinha+P%22">Sinha P</searchLink>; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Antcliffe+DB%22">Antcliffe DB</searchLink>; Division of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McDowell+C%22">McDowell C</searchLink>; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+PA%22">Bradley PA</searchLink>; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Black+L%22">Black L</searchLink>; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+L%22">Murphy L</searchLink>; Northern Ireland Clinical Trials Unit, Belfast Health and Social Care Trust, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Barbaras+J%22">Barbaras J</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Conlon+J%22">Conlon J</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Camporota+L%22">Camporota L</searchLink>; Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, King's Health Partners, London, UK; Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ostermann+M%22">Ostermann M</searchLink>; Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, King's Health Partners, London, UK.<br /><searchLink fieldCode="AU" term="%22Hopkins+P%22">Hopkins P</searchLink>; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Szakmany+T%22">Szakmany T</searchLink>; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK; Critical Care Directorate, Royal Gwent Hospital, Newport, UK.<br /><searchLink fieldCode="AU" term="%22Cherian+S%22">Cherian S</searchLink>; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK; Critical Care Directorate, Royal Gwent Hospital, Newport, UK.<br /><searchLink fieldCode="AU" term="%22Welters+I%22">Welters I</searchLink>; Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK; Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Brealey+D%22">Brealey D</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK; Division of Critical Care, University College London Hospitals, London, UK.<br /><searchLink fieldCode="AU" term="%22Parekh+D%22">Parekh D</searchLink>; Birmingham Acute Care Research Group, University of Birmingham, Birmingham, UK; Department of Anaesthetics and Critical Care, Queen Elizabeth Hospital, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Rostron+AJ%22">Rostron AJ</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK; Department of Anaesthesia and Intensive Care Medicine, Sunderland Royal Hospital, Sunderland, UK.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care and Laboratory of Experimental Intensive Care and Anaesthesiology, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Nichol+A%22">Nichol A</searchLink>; Department of Critical Care Medicine, School of Medicine, University College Dublin, Health Sciences Centre, Belfield, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Shankar-Hari+M%22">Shankar-Hari M</searchLink>; Centre for Critical Illness Research, King's College London, London, UK; Institute for Regeneration and Repair, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Gordon+AC%22">Gordon AC</searchLink>; Division of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Delucchi+K%22">Delucchi K</searchLink>; Department of Psychiatry and Behavioural Sciences, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22O'Kane+CM%22">O'Kane CM</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Matthay+MA%22">Matthay MA</searchLink>; Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Calfee+CS%22">Calfee CS</searchLink>; Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22McAuley+DF%22">McAuley DF</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK; Royal Victoria Hospital, Belfast, UK.
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  Data: <searchLink fieldCode="JN" term="%22101605555%22">The Lancet. Respiratory medicine</searchLink> [Lancet Respir Med] 2026 Jul; Vol. 14 (7), pp. 589-600. <i>Date of Electronic Publication: </i>2026 Mar 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101605555 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2619 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132600%22">22132600 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Respir Med <i>Subsets: </i>MEDLINE
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